945651-35-4Relevant academic research and scientific papers
Process for the preparation of Lubiprostone and intermediates thereof
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Page/Page column 23, (2019/11/11)
The present invention relates to a novel process for preparing Lubiprostone and novel intermediates prepared from the process. The process of the present invention does not generate hydrogenated by-products that are difficult to be removed, and thus enables the production of Lubiprostone in an efficient and economical way.
NOVEL SYNTHESIS ROUTES FOR PROSTAGLANDINS AND PROSTAGLANDIN INTERMEDIATES USING METATHESIS
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Page/Page column 86; 109, (2015/04/15)
Methods of synthesizing prostaglandins, prostaglandin analogs and their synthetic intermediates are described. The methods can comprise metal- catalyzed metathesis reactions. Also provided are synthetic intermediates that can be used in the synthesis of t
Method for preparing 15-keto-prostaglandin E derivative
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Page/Page column 6; 7-8, (2008/06/13)
Disclosed is an improved method for preparing 15-keto-prostaglandin E derivative. According to the invention, the deprotection of protected hydroxy group required in manufacturing a 15-keto-prostaglandin derivative is conducted under the presence of a pho
Method for preparing prostaglandin derivative
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Page/Page column 17-18, (2010/11/28)
Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
