945674-83-9Relevant academic research and scientific papers
Antitumor agents: Development of highly potent glycosidic duocarmycin analogues for selective cancer therapy
Tietze, Lutz F.,Major, Felix,Schuberth, Ingrid
, p. 6574 - 6577 (2006)
(Chemical Equation Presented) Better and better: The glycosidic prodrug (+)-1, which is based on duocarmycin antibiotics, was synthesized for selective cancer therapy. The drug was developed within the context of "antibody-directed enzyme prodrug therapy"
Selective treatment of cancer: Synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins
Tietze, Lutz F.,Major, Felix,Schuberth, Ingrid,Spiegl, Dirk A.,Krewer, Birgit,Maksimenka, Katja,Bringmann, Gerhard,Magull, Joerg
, p. 4396 - 4409 (2008/02/08)
Novel diastereomerically pure β-D-galactosidic prodrugs (+)-12a-e of the cytotoxic antibiotics CC-1065 and the duocarmycins were prepared for an antibody directed enzyme prodrug therapy (ADEPT) using 4 as a substrate via a radical cyclization to give rac-
