945721-10-8

Basic information

• Product Name: 7-O-ethyl-Morroniside
• Synonyms: 7-O-ethyl-Morroniside;(1S,3R,4aS,8S,8aS)-3-Ethoxy-8-(beta-D-glucopyranosyloxy)-4,4a,8,8a-tetrahydro-1-methyl-1H,3H-pyrano[3,4-c]pyran-5-carboxylic acid methyl ester;O-Ethylmorroniside, 7-
• CAS NO: 945721-10-8
• Molecular Formula: C19H30O11
• Molecular Weight: 434.4349
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 945721-10-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 611.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• PKA: 12.80±0.70(Predicted)
• CAS DataBase Reference: 7-O-ethyl-Morroniside(CAS DataBase Reference)
• NIST Chemistry Reference: 7-O-ethyl-Morroniside(945721-10-8)
• EPA Substance Registry System: 7-O-ethyl-Morroniside(945721-10-8)

Safety Data

• Hazardous Substances Data: 945721-10-8(Hazardous Substances Data)

Usage

Uses

7-O-Ethylmorroniside is a derivative of Morroniside (M725700), a pharmaceutical agent improving microvascular functional integrity and vascular elements of the neurovascular unit in the treatment of cerebral ischemia.

Upstream product

• 64-17-5 ethanol 
• 25406-64-8 morroniside 

Relevant articles and documents

Synthesis and promotion of the osteoblast proliferation effect of morroniside derivatives

Sambucus williamsii Hance has been used in fractures for thousands of years, but research on its active components, such as morroniside, until now had not been carried out. In this study, morroniside was taken as the leading compound, and fourteen derivatives were synthesized. The promotion of osteoblast proliferation effect of the derivatives was evaluated on MC3T3-E1 cells. Five derivatives (2, 3, 4, 5, and 14) showed a good proliferation effect on MC3T3-E1 cells, and their promoted expression effects on OC (Osteocalcin) and ALP (Alkaline phosphatase) in MC3T3-E1 cells were measured. Compound 3 was shown to have the strongest proliferation effect (EC50 = 14.78 ± 1.17 μg/mL) and to significantly promote the expression of OC and ALP.