25406-64-8

Basic information

• Product Name: Morroniside
• Synonyms: Morroniside;(1S,3R,4aS,8S,8aS)-8-(beta-D-Glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-1H,3H-pyrano[3,4-c]pyran-5-carboxylic acid methyl ester;8-(β-D-Glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-1H,3H-pyrano[3,4-c]pyran-5-carboxylic acid methyl ester;Morronisid;Morroniside, 98%, from Cornus officinalis Sieb. et Zucc.
• CAS NO: 25406-64-8
• Molecular Formula: C₁₇H₂₆O₁₁
• Molecular Weight: 406.38
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 25406-64-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 635.6oC at 760 mmHg
• Flash Point: 226.9oC
• Appearance: /
• Density: 1.52
• Vapor Pressure: 7.9E-19mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.54±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Morroniside(CAS DataBase Reference)
• NIST Chemistry Reference: Morroniside(25406-64-8)
• EPA Substance Registry System: Morroniside(25406-64-8)

Safety Data

• Hazardous Substances Data: 25406-64-8(Hazardous Substances Data)

Usage

Uses

Morroniside is a pharmaceutical agent improving microvascular functional integrity and vascular elements of the neurovascular unit in the treatment of cerebral ischemia.

InChI:InChI=1/C17H26O11/c1-6-11-7(3-10(19)26-6)8(15(23)24-2)5-25-16(11)28-17-14(22)13(21)12(20)9(4-18)27-17/h5-7,9-14,16-22H,3-4H2,1-2H3/t6-,7+,9+,10+,11+,12+,13-,14+,16-,17-/m0/s1

Downstream Products

• 945721-10-8 7-O-ethylmorroniside 
• 41679-97-4 7-O-methylmorroniside 

Relevant articles and documents

INTERMEDIACY OF 6-HYDROXYLOGANIN IN THE RING CLEAVAGE COURSE OF LOGANIN TO SECOLOGANIN

A possible biosynthetic pathway from loganin to secologanin through ring cleavage of 6-hydroxyloganin was ruled out in feeding experiments in which Eustoma russellianum, Swertia japonica, Lonicera morrowii and Adina pilulifera were each presented with three C-6 and C-7 stereoisomers of hydroxy -loganin as well as - and -loganin.In an associated experiment, the reduction of the aldehyde group of secologanin leading to sweroside was shown to proceed by hydride ion attack from the si face.Key Word Index - Biosynthesis; ring cleavage; loganin; 6,7-stereoisomer of 6-hydroxyloganin; secologanin; stereochemical course of the reduction; deuterium labelling.