945738-72-7

Upstream product

• 945738-71-6 2-amino-pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione 
• 14215-97-5 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose 
• 29668-91-5 2-amino-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 

Relevant academic research and scientific papers

Guanosine analog in the pyrido[2,3-d]pyrimidine ring system as a potential toll-like receptor agonist

The synthesis of a guanosine analog in the pyrido[2,3-d]pyrimidine ring system has been accomplished by glycosylation of the preformed aromatic heterocyclic base, which was prepared in 2 steps by condensation of methyl acrylate with guanidine carbonate an

Combined use of IMPDH inhibitors with toll-like receptor agonists

The present invention provides a broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal and treating diseases such as cancer and autoimmune disease. These agents include TLR-ligands and ligand analogs which induce interferon production, in combination with inhibitors of inosine monophosphate dehydrogenase (IMPDH), that further enhance the induction of interferon production.