94576-64-4

Upstream product

• 86-29-3 Diphenylacetonitrile 
• 621-62-5 chloroacetaldehyde diethyl acetal 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 

Downstream Products

• 28168-63-0 4-Amino-3.3-diphenyl-butanal-diethylacetal 
• 92855-33-9 4-Oxo-2,2-diphenylbutyronitril 
• 101877-34-3 (+/-)-4-hydroxy-2,2-diphenylvaleronitril 
• 115031-78-2 (7α,8aβ)-4-amino-5-chloro-2-methoxy-N-(octahydro-2,2-diphenylindolizin-7-yl)benzamide 
• 115031-85-1 2,2-Diphenyl-hexahydro-indolizin-7-one 
• 115031-81-7 (7R,8aR)-2,2-Diphenyl-octahydro-indolizin-7-ylamine 

Relevant academic research and scientific papers

Chiral Br?nsted Acid Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes

The first highly efficient and practical chiral Br?nsted acid catalyzed dynamic kinetic asymmetric hydroamination (DyKAH) of racemic allenes and asymmetric hydroamination of unactivated dienes with both high E/Z selectivity and enantioselectivity are described herein. The transformation proceeds through a new catalytic asymmetric model involving a highly reactive π-allylic carbocationic intermediate, generated from racemic allenes or dienes through a proton transfer mediated by an activating/directing thiourea group. This method affords expedient access to structurally diverse enantioenriched, potentially bioactive alkenyl-containing aza-heterocycles and bicyclic aza-heterocycles.

Substituted Benzamides with Conformationally Restricted Side Chains. 2. Indolizine Derivatives as Central Dopamine Receptor Antagonists

The substituted benzamides metoclopramide (1) and clebopride (3) are stimulants of gastric molitity.They are also central dopamine receptor antagonists with 3 being the more potent.This is presumed to be due to an additional interaction of its N-benzyl gr