101877-34-3Relevant academic research and scientific papers
Method for preparing gamma-alcoholic compound containing nitrile group
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Paragraph 0027-0033, (2019/07/04)
The invention discloses a method for preparing a gamma-alcoholic compound containing a nitrile group, and belongs to the technical field of organic synthesis. The method comprises the steps that a nitrile-based compound containing alpha-H is mixed with me
A novel approach to isomeric pure (±)-methadone
Bracher, Franz,Klein, Katrin,Litz, Thomas
, p. 271 - 278 (2007/10/03)
Alkylation of deprotonated diphenylacetonitrile (2) with an acetal of chloroacetone followed by acidic hydrolysis and reductive amination of the resulting ketonitrile 12 offered an easy access to the methadone precursor 3. By this pathway the formation of the undesired regioisomer 4 was avoided.
