945845-03-4Relevant articles and documents
The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors
Grice, Cheryl A.,Tays, Kevin,Khatuya, Haripada,Gustin, Darin J.,Butler, Christopher R.,Wei, Jianmei,Sehon, Clark A.,Sun, Siquan,Gu, Yin,Jiang, Wen,Thurmond, Robin L.,Karlsson, Lars,Edwards, James P.
, p. 2209 - 2212 (2007/10/03)
A series of competitive, reversible cathepsin S (CatS) inhibitors was investigated. An earlier disclosure detailed the discovery of the 4-(2-keto-1-benzimidazolinyl)-piperidin-1-yl moiety as an effective replacement for the 4-arylpiperazin-1-yl group foun