945857-66-9Relevant academic research and scientific papers
Double axially chiral bisphosphorylimides catalyzed highly enantioselective and efficient friedel-crafts reaction of indoles with imines
Wu, Kun,Jiang, Yi-Jun,Fan, Yan-Sen,Sha, Di,Zhang, Suoqin
supporting information, p. 474 - 478 (2013/02/23)
Cool cats: 1,1′-Bi-2-naphthol and vaulted 3,3′-biphenanthrol- type bisphosphorylimides enabled the atom-economical and highly enantioselective Friedel-Crafts reaction between indoles and N-tosylimines with a low catalyst loading (see scheme). A very small
Chiral sulfonimide as a bronsted acid organocatalyst for asymmetric Friedel-Crafts alkylation of indoles with imines
Chen, Ling-Yan,He, Hao,Chan, Wing-Hong,Lee, Albert W. M.
experimental part, p. 7141 - 7147 (2011/10/09)
Binaphthyl-based chiral sulfonimide (CSI) is demonstrated for the first time to be an efficient, strong Bronsted acid in asymmetric organocatalysis. A series of CSIs were synthesized and screened in the asymmetric Friedel-Crafts alkylation of indoles with imines. Good to excellent yields and enantioselectivities have been achieved. It was proved that it was crucial to wash the CSI catalyst with HCl before use.
