160955-96-4

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 591-31-1 3-methoxy-benzaldehyde 
• 672-78-6 methyl p-toluene sulfinate 
• 6873-55-8 p-tolylsulfinyl amide 
• 103-19-5 di(p-tolyl) disulfide 
• 871939-86-5 4-Methyl-benzenesulfinic acid 1-(3-methoxy-phenyl)-meth-(E)-ylideneamide 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 127-65-1 chloroamine-T 
• 6971-51-3 3-methoxybenzyl alcohol 

Downstream Products

• 1020398-78-0 bis(4-methoxyphenyl)(3-methoxyphenyl)methane 
• 1373874-16-8 C₂₅H₂₃N₃O₃S 
• 945857-66-9 C₂₃H₂₂N₂O₃S 
• 1323421-28-8 S-tert-butyl (S)-3-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)propanethioate 
• 1245746-88-6 (4R,5S)-4-(methoxycarbonyl)-5-(3-methoxyphenyl)-N-tosyl-2-imidazoline 
• 1152292-52-8 (R)-N-[1-(3-methoxyphenyl)-2-methylene-3-oxobutyl]-4-methylbenzenesulfonamide 
• 1417742-38-1 (S)-N-[1-(3-methoxyphenyl)-2-methylene-3-oxobutyl]-4-methylbenzenesulfonamide 
• 1073118-15-6 (syn)-methyl 2-[(diphenylmethylene)amino]-3-(m-methoxyphenyl)-3-(p-toluenesulfonylamino)propanoate 

Relevant academic research and scientific papers

The diastereoselective synthesis of 2,3-diaryl-3-cyano-substituted pyrrolidines via the MgI2 mediated ring expansion of aryl cyclopropyl nitriles

The MgI2 mediated reaction of aryl substituted cyclopropyl nitriles with tosyl aldimines to give 2,3-diaryl-3-cyano-substituted pyrrolidines has been demonstrated. In all cases, the trans-diastereoisomer was determined to be the major product.

NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant

A nickel-catalyzed reductive coupling of alkynes and imines using readily available isopropanol as the reducing agent was developed. The use of a sterically bulky and electron-rich carbene ligand (AnIPr) significantly promotes the reaction, providing various multi-substituted allylic amines in 23-89% yield and the corresponding chiral ligand (AnIPr-3) can afford the products in 51-95% ee.

Alkenyl Exchange of Allylamines via Nickel(0)-Catalyzed C-C Bond Cleavage

A functional group exchange reaction between allylamines and alkenes via nickel-catalyzed C - C bond cleavage and formation was developed. This reaction provides a novel protocol, which does not require the use of unstable imine substrates, for the synthesis of allylamines, which are widely used in the production of fine chemicals, pharmaceuticals, and agrochemicals.

Visible-light, iodine-promoted formation of n-sulfonyl imines and n-alkylsulfonamides from aldehydes and hypervalent iodine reagents

Alternative synthetic methodology for the direct installation of sulfonamide functionality is a highly desirable goal within the domain of drug discovery and development. The formation of synthetically valuable N-sulfonyl imines from a range of aldehydes,

Formation of: N -sulfonyl imines from iminoiodinanes by iodine-promoted, N-centered radical sulfonamidation of aldehydes

A mild and operationally convenient formation of synthetically valuable N-sulfonyl imines from a range of aryl aldehydes by reaction with iminoiodinanes (PhINZ) and I2 has been developed. According to mechanistic experiments described within, the reaction is speculated to proceed through an unconventional light-promoted, N-centered radical (NCR) pathway involving a N,N-diiodosulfonamide reactive species. This method not only provides a new pathway toward the production of activated imines, but also serves as an example of a non-traditional means of carbonyl activation via an NCR species.

Hydrogen peroxide/dimethyl carbonate: A green system for epoxidation of: N -alkylimines and N -sulfonylimines. One-pot synthesis of N -alkyloxaziridines from N -alkylamines and (hetero)aromatic aldehydes

A green method for epoxidation of imines using an environmentally benign oxidant system, H2O2/dimethyl carbonate, was developed. N-Alkyloxaziridines were prepared in high yields from N-alkylamines and (hetero)aromatic aldehydes in one-pot fashion, whereas N-sulfonyloxaziridines have been prepared by using the same oxidant system and 5 mol% of Zn(OAc)2·2H2O as catalyst.

An organocatalytic synthesis of N-sulfonyl imines using chloramine-T in aqueous medium

N-Sulfonyl imines have been synthesized in good to excellent yields from aldehydes and chloramine-T using proline as an organocatalyst in aqueous medium at ambient temperature. The protocol is applicable to a wide range of aldehydes, especially enals exhi

A Mannich/cyclization cascade process for the asymmetric synthesis of spirocyclic thioimidazolidineoxindoles

An asymmetric cascade Mannich/cyclization reaction between 3-isothiocyanato oxindoles and sulfimides using a commercially available organocatalyst has been developed. A wide range of structurally diverse spiro[imidazolidine-4,3′-oxindole] derivatives were

α-Aryl-substituted allenamides in an imino-nazarov cyclization cascade catalyzed by Au(I)

An imino-Nazarov cyclization using α-aryl-substituted allenamides is described. This gold(I)-catalyzed cascade is efficient and regioselective in constructing a diverse array of synthetically useful aromatic-ring fused cyclopentenamides. The success in this transformation represents a solution to the challenge in establishing an imino-Nazarov cyclization process.

One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis

An efficient, easy to perform, one-pot reaction cascade for the synthesis of 2,5-disubstituted pyrroles from p-toluenesulfonyl protected imines and 4-nitrobut-1-yne under a combination of base and gold(iii) catalysis is reported.