945860-87-7

Upstream product

• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 540-72-7 sodium thiocyanide 
• 333-20-0 potassium thioacyanate 
• 133033-21-3 2-(4-(trifluoromethyl)phenyl)acrylic acid 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 945860-88-8 2-chloro-4-(4-(trifluoromethyl)phenyl)thiazole 
• 1095110-60-3 4-(4-trifluoromethylphenyl)-2-oxo-thiazole 
• 1232234-31-9 2-azido-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid 
• 1232234-32-0 2-azido-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide 
• 1188045-45-5 2-chloro-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid ethyl ester 
• 1232234-29-5 2-amino-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide 
• 1232234-30-8 2-azido-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid ethyl ester 
• 1232235-14-1 2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide 
• 1232235-13-0 2-(5-dimethoxymethyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide 
• 1232234-17-1 2-[6-(4-Methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide 
• 1232235-15-2 2-[5-(4-methyl-piperazin-1-ylmethyl)-2-nitro-phenylamino]-4-(4-trifluoromethyl-phenyl)thiazole-5-carboxylic acid amide 

Relevant academic research and scientific papers

Visible-Light-Mediated Additive-Free Decarboxylative Ketonization Reaction of Acrylic Acids: An Access to α-Thiocyanate Ketones

Visible-light-mediated additive-free decarboxylative functionalization of acrylic acids has been developed. The reaction uses inexpensive organic dye 9,10-dicyanoanthracene as a photocatalyst and uses the ubiquitous dioxygen as both an oxygen source and an oxidant. Through this mild and environmentally friendly method, a series of important α-thiocyanate ketones can be generated from easily available acrylic acids and ammonium thiocyanate. In addition, the facile transformation of product α-thiocyanate ketones makes this method have great potential for application in organic and pharmaceutical chemistry.

SUBSTITUTED PYRAZOLE COMPOUNDS AND METHODS OF USING THEM FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES

Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for

Thiazolyl-Benzimidazoles

The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.