945920-36-5Relevant academic research and scientific papers
One-pot synthesis of 2-acylbenzothiazoles from 2-aminobenzenethiols and arylacetonitriles via cyclization and sequential oxidation
Zhang, Shanshan,Wang, Shiwei,Leng, Yuting,Wu, Yangjie
supporting information, (2021/08/13)
An efficient one-pot method to access 2-acylbenzothiazoles via AlCl3-mediated cyclization reaction and I2-promoted sequential oxidation reaction of 2-aminobenzenethiols with arylacetonitriles was developed. This reaction proceeds smoothly with a wide range of arylacetonitriles containing different functional groups to give the corresponding products in moderate to good yields under mild conditions. Moreover, this reaction was conveniently conducted on a gram scale, and the yield is still up to 68%.
C2-arylacylation of 2H-benzothiazoles with methyl arenes via Selectfluor oxidation
Chen, Bo,Kong, Yao-Lei,Liu, Jin-Chuan,Lu, Qi,Sun, Xiao-Tong,Weng, Jian-Quan
supporting information, (2021/06/03)
An efficient Selectfluor-oxidative protocol was developed for the direct C2-arylacylation of 2H-benzothiazoles via the radical reaction of 2H-benzothiazoles with methyl arenes. Selectfluor can effectively promote the oxidative cross-coupling without an ex
Iodine- And TBHP-Promoted Acylation of Benzothiazoles under Metal-Free Conditions
Wang, Bin,Zhang, Qianwei,Guo, Zhongqi,Ablajan, Keyume
, p. 3058 - 3064 (2020/08/28)
A simple protocol for the synthesis of 2-acylbenzothiazoles using aryl ketones and benzothiazoles in the presence of I 2and TBHP is described. Acylation of the benzothiazoles is achieved through a sequence involving oxidation of the aryl ketone to an aryl glyoxal, ring-opening of the benzothiazole followed by condensation of the amino group with the aryl glyoxal, cyclization and oxidation. The method avoids the use of metals and toxic solvents. In addition, this protocol has the advantage of broad scope and provides good to excellent product yields.
A multipathway coupled domino strategy: Metal-free oxidative cyclization for one-pot synthesis of 2-acylbenzothiazoles from multiform substrates
Zhu, Yan-Ping,Jia, Feng-Cheng,Liu, Mei-Cai,Wu, An-Xin
, p. 4414 - 4417 (2012/10/29)
A multipathway coupled domino strategy has been developed for the efficient synthesis of 2-acylbenzothiazoles from multiform substrates arylethenes, arylacetylenes, 2-hydroxy-aromatic ketones, and carbinols via four distinct pathways. Through a logical coupled oxidation/heterocyclization domino process, a variety of 2-acylbenzothiazoles were synthesized free of metal in one pot.
A sustainable synthesis of 2-benzoxazyl and 2-benzothiazyl ketones from alkynyl bromides and 2-amino(thio)phenols promoted by a recyclable catalytic system
Cui, Liangyan,He, Yan,Fan, Xuesen
experimental part, p. 992 - 996 (2012/05/20)
An environmentally and economically sustainable synthesis of 2-benzoxazyl ketones and 2-benzothiazyl ketones through FeCl3·6H 2O catalyzed tandem reactions of alkynyl bromides with 2-amino(thio)phenols in [bmim]BF4 has been developed. Remarkable advantages of this new synthetic strategy include high efficiency, readily available starting materials, and recyclable catalyst and reaction medium. An environmentally and economically sustainable synthesis of 2-benzoxazyl ketones and 2-benzothiazyl ketones through FeCl3·6H2O catalyzed tandem reactions of alkynyl bromides with 2-amino(thio)phenols in [bmim]BF4 has been developed. Remarkable advantages of this new synthetic strategy include high efficiency, readily available starting materials, and recyclable catalyst and reaction medium. Copyright
Rucl33h2o catalyzed tandem reaction of alkynylbromides with 2-aminothiophenols in water: A convenient synthesis of 2-benzoylbenzothiazoles
Fan, Xuesen,He, Yan,Guo, Shenghai,Zhang, Xinying
experimental part, p. 1568 - 1573 (2012/01/14)
RuCl33H2O catalyzed tandem reaction of alkynyl bromides with 2-aminothiophenols mediated by water is shown to represent a convenient synthesis of 2-benzoylbenzothiazoles. In addition, the Ru(iii) catalyst could be readily recovered and efficiently reused together with water up to three times. CSIRO 2011.
Synthesis of heteroaryl ketones via tandem reaction of 1,1-dibromoethenes
Fan, Xuesen,He, Yan,Zhang, Xinying,Guo, Shenghai,Wang, Yangyang
experimental part, p. 6369 - 6374 (2011/09/12)
A novel method for the synthesis of heteroaryl ketones through one-pot tandem reaction of 1,1-dibromoethenes with 2-amino(thio)phenols promoted by TBAF·3H2O and RuCl3(5%)/air was developed. This novel method includes several reactions in one-pot and utilizes economical yet efficient reagents to generate synthetically and biologically interesting heteroaryl ketones under mild conditions with good efficiency.
A novel and practical synthesis of 2-benzoylbenzothiazoles and 2-benzylbenzothiazoles
Fan, Xuesen,He, Yan,Wang, Yangyang,Xue, Zaikun,Zhang, Xinying,Wang, Jianji
experimental part, p. 899 - 902 (2011/03/18)
A novel methodology for the synthesis of 2-benzoylbenzothiazoles and 2-benzylbenzothiazoles through FeCl3·6H2O catalyzed, air oxidized tandem process from commercially available 2-aminothiophenols and phenylacetaldehydes by using an
