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Upstream product

• 115769-03-4 2-(2-bromophenyl)imidazo[1,2-α]pyridine 
• 49851-55-0 2,2'-dibromoacetophenone 
• 552-89-6 2-nitro-benzaldehyde 
• 100-19-6 (4-nitrophenyl)ethanone 
• 126267-63-8 2-(2-nitro-phenyl)-imidazo[1,2-a]pyridine 
• 253684-24-1 1-(2,2-dibromovinyl)-2-nitrobenzene 
• 504-29-0 2-aminopyridine 

Relevant academic research and scientific papers

One-pot sequential reactions featuring a copper-catalyzed amination leading to pyrido[2′,1′:2,3]imidazo[4,5-c]quinolines and dihydropyrido[2′,1′:2,3]imidazo[4,5-c]quinolines

Tetracyclic skeletons combining an imidazo[1,2-a]pyridine moiety with a quinoline framework such as pyrido[2′,1′:2,3]imidazo[4,5-b]quinoline are stimulating increasing interests since they are close isosteres of a series of powerful antiproliferative comp

Synthesis of biologically active pyridoimidazole/imidazobenzothiazole annulated polyheterocycles using cyanuric chloride in water

An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet-Spengler type 6-endo cyclization using cyanuric chloride in an aqueous reaction medium has been developed. The protocol was successfully applied to a wide range of compounds including aryl/heteroaryl aldehydes (8a-o), ketones (10a-e), an electron-rich metallocene aldehyde (8e) and indoline-2,3-diones (12a-c) using cyanuric chloride (15-20 mol%) with tetra-n-butylammonium bromide (TBAB) (2.0 eq.) as an additive at 80-90 °C to give a good to excellent yield (66-92%) of polyheterocycles. Some of the synthesized compounds were found to exhibit antiplasmodial activity against chloroquine-sensitive (CQ-S) 3D7 and chloroquine-resistant (CQ-R) K1 strains of Plasmodium falciparum. This journal is the Partner Organisations 2014.