126267-63-8

Usage

Uses

Used in Pharmaceutical Research and Development:
2-(2-nitrophenyl)H-iMidazo[1,2-a]pyridine is used as a research compound for exploring its potential as a therapeutic agent. It is being studied for its possible applications in treating various conditions, such as cancer and neurological disorders, due to its unique chemical structure and properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(2-nitrophenyl)H-iMidazo[1,2-a]pyridine serves as a key compound for investigating its interactions with biological targets. Its structure allows for the design and synthesis of new drug candidates that can modulate specific biological pathways, offering potential treatments for a range of diseases.
Used in Materials Science:
2-(2-nitrophenyl)H-iMidazo[1,2-a]pyridine also has potential applications in materials science. Its unique molecular structure can be leveraged to develop new materials with specific properties, such as optical, electronic, or mechanical characteristics, which can be utilized in various industries.
Used in Organic Synthesis:
In organic synthesis, 2-(2-nitrophenyl)H-iMidazo[1,2-a]pyridine can be employed as a building block or intermediate in the synthesis of more complex organic molecules. Its reactivity and functional groups make it a valuable component in the creation of novel compounds with diverse applications.

Upstream product

• 504-29-0 2-aminopyridine 
• 6851-99-6 2-bromo-1-(2-nitrophenyl)ethanone 
• 253684-24-1 1-(2,2-dibromovinyl)-2-nitrobenzene 
• 552-89-6 2-nitro-benzaldehyde 
• 577-59-3 2-acetylnitrobenzene 
• 10342-62-8 1-(2-nitro-phenyl)-ethanone oxime 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 110-86-1 pyridine 
• 1562372-97-7 C₁₀H₉N₅O₂ 

Downstream Products

• 1621431-71-7 6-phenylpyrido[2′,1′:2,3]imidazo[4,5-c]quinoline 
• 945933-92-6 6-(4-nitrophenyl)pyrido[2',1':2,3]imidazo[4,5-c]quinoline 
• 1621431-72-8 6-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c]quinoline 
• 1621431-73-9 6-(4-methoxyphenyl)pyrido[2',1':2,3]imidazo[4,5-c]quinoline 
• 945933-96-0 6-methyl-6-phenyl-5,6-dihydropyrido[2',1':2,3]imidazo[4,5-c]quinoline 
• 945933-99-3 6-methyl-6-(4-nitrophenyl)-5,6-dihydropyrido[2',1':2,3]imidazo[4,5-c]quinoline 
• 945933-98-2 6-(4-methoxyphenyl)-6-methyl-5,6-dihydropyrido[2',1':2,3]imidazo[4,5-c]quinoline 
• 1621431-88-6 6-(4-bromophenyl)-6-methyl-5,6-dihydropyrido[2',1':2,3]imidazo[4,5-c]quinoline 
• 126267-71-8 6-(2-chlorophenyl)pyrido(1',2':1,2)imidazo(5,4-d)(1.3)benzodiazepine 
• 126267-70-7 3-((N-2-chlorobenzylidene)-amino)-2-imidazo(1,2-a)pyridinyl-2,2'-aminobenzene 
• 126267-65-0 2-(2-Nitro-phenyl)-imidazo[1,2-a]pyridin-3-ylamine 
• 126267-69-4 2-(2-Amino-phenyl)-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-3-ylamine 
• 126267-66-1 2-(2-aminophenyl)-3-aminoimidazo(1,2-a)pyridine 
• 126267-67-2 (2-Amino-phenyl)-[(Z)-pyridin-2-ylimino]-acetonitrile 

Relevant academic research and scientific papers

An expeditious microwave assisted one-pot sequential route to pyrido fused imidazo[4,5-c] quinolines in green media

An expeditious microwave assisted one-pot sequential route to synthesize pyrido fused imidazo[4,5-c]quinolinesviathe Pictet-Spengler cyclization strategy has been developed. In this study, substituted 2-amino pyridines are condensed with 2-bromo-2′-nitroa

6π-Electrocyclization in water: microwave-assisted synthesis of polyheterocyclic-fused quinoline-2-thiones

Microwave-assisted synthesis of polyheterocyclic-fused quinoline-2-thiones through the annulation of ortho-heteroaryl anilines and CS2 was realized in water without using any catalysts and additives. The desired products were obtained in high yields throu

CuCl2-catalyzed N[sbnd]O bond cleavage of oxime esters: Approach to imidazoheterocycles and furo[3,2-c]chromenyl fused imidazoles

An articulate approach to a diverse set of imidazoheterocycles in good to high yields via a copper-catalyzed aza-annulation of several oxime esters with a group of 2-amino-azaarenes was developed. The above cyclization reaction probably proceeds via a single electron transfer process which embodies a new technique for creating two new C[sbnd]N bonds for imidazole ring synthesis. Gratifyingly, the implementation of this chemistry could be further stretched to the synthesis of a novel class of fused imidazoles bearing a furo[3,2-c]chromene moiety via a sequential C[sbnd]N bond formation, followed by C(sp2)-H functionalization/5-endo-dig-oxacyclization (C[sbnd]C and C[sbnd]O bonds) of in situ produced fused imidazoles with cyclic enynones in the presence of copper(II) as a π-electrophilic Lewis acid catalyst.

Hypervalent iodine promoted: Ortho diversification: 2-aryl benzimidazole, quinazoline and imidazopyridine as directing templates

The mild and efficient palladium-catalyzed ortho C(sp2)-H diversification of (NH)-free 2-substituted benzimidazole, quinazoline, and imidazopyridine is reported using hypervalent iodine as the key reagent. Acetoxy, aryl, iodide and nitro functi

Efficient Access to Imidazo[1,2- a] pyridines/pyrazines/pyrimidines via Catalyst-Free Annulation Reaction under Microwave Irradiation in Green Solvent

An expeditious catalyst-free heteroannulation reaction for imidazo[1,2-a]pyridines/pyrimidines/pyrazines was developed in green solvent under microwave irradiation. Using H2O-IPA as the reaction medium, various substituted 2-aminopyridines/pyra

Indole heterocyclic compound and organic light-emitting device thereof

The invention provides an indole heterocyclic compound and an organic light-emitting device thereof, and relates to the technical field of organic light-emitting materials. The heterocyclic compound contains three nitrogen atoms capable of attracting elec

COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME

An organic light-emitting device including a first electrode; a second electrode facing the first electrode; and an organic layer that is between the first electrode and the second electrode and includes an emission layer, wherein the organic layer includ

Tert -Butyl nitrite (TBN) as the N atom source for the synthesis of substituted cinnolines with 2-vinylanilines and a relevant mechanism was studied

A green method to synthesize cinnolines by 6π electrocyclic reaction with alkenyl amines and TBN has been developed. TBN plays a dual role both as a nitrogen atom source and an oxidant in this procedure. Relevant mechanism experiments reveal that the reaction proceeds through electrocyclic reaction and with diazo hydroxide as a key intermediate.

A new class of N-H excited-state intramolecular proton transfer (ESIPT) molecules bearing localized zwitterionic tautomers

A series of new amino (NH)-type intramolecular hydrogen-bonding (H-bonding) compounds have been strategically designed and synthesized. These molecules comprise a 2-(imidazo[1,2-a]pyridin-2-yl)aniline moiety, in which one of the amino hydrogens was replaced with substituents of different electronic properties. This, together with the versatile capability for modifying the parent moiety, makes feasible comprehensive spectroscopy and dynamics studies of excited-state intramolecular proton transfer (ESIPT) as a function of N-H acidity. Different from other (NH)-type ESIPT systems where the ESIPT rate and exergonicity increase with an increase in the N-H acidity and hence the H-bonding strength, the results reveal an irregular relationship among ESIPT dynamics, thermodynamics and H-bond strength. This discrepancy may be rationalized by the localized zwitterionic nature of 2-(imidazo[1,2-a]pyridin-2-yl)aniline in the proton-transfer tautomer form, which is different from the π-delocalized tautomer form in other (NH)-type ESIPT systems.

Synthesis of biologically active pyridoimidazole/imidazobenzothiazole annulated polyheterocycles using cyanuric chloride in water

An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet-Spengler type 6-endo cyclization using cyanuric chloride in an aqueous reaction medium has been developed. The protocol was successfully applied to a wide range of compounds including aryl/heteroaryl aldehydes (8a-o), ketones (10a-e), an electron-rich metallocene aldehyde (8e) and indoline-2,3-diones (12a-c) using cyanuric chloride (15-20 mol%) with tetra-n-butylammonium bromide (TBAB) (2.0 eq.) as an additive at 80-90 °C to give a good to excellent yield (66-92%) of polyheterocycles. Some of the synthesized compounds were found to exhibit antiplasmodial activity against chloroquine-sensitive (CQ-S) 3D7 and chloroquine-resistant (CQ-R) K1 strains of Plasmodium falciparum. This journal is the Partner Organisations 2014.