945950-37-8

Basic information

• Product Name: 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine
• Synonyms: 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine
• CAS NO: 945950-37-8
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.15058
• Mol File: 945950-37-8.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Density: 1.273±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.44±0.50(Predicted)
• CAS DataBase Reference: 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine(945950-37-8)
• EPA Substance Registry System: 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine(945950-37-8)

Safety Data

• Hazardous Substances Data: 945950-37-8(Hazardous Substances Data)

Usage

Uses

4-Methyl-7H-pyrrolo[2,3-d]pyrimidine can be used as biomarkers to identify patients that might potentially be responsive to prmt5 inhibitor treatment.

Upstream product

• 14618-78-1 4,4-dimethoxybutanenitrile 
• 3473-63-0 formamidine acetic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 71-36-3 butan-1-ol 
• 1634-04-4 tert-butyl methyl ether 
• 14024-18-1 tris(((Z)-4-oxopent-2-en-2-yl)oxy)iron 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 67-63-0 isopropyl alcohol 
• 298-06-6 O,O-Diethyl hydrogen phosphorodithioate 
• 89792-07-4 2-methyl-7H-pyrrolo[2,3-d]pyrimidine 
• 271-70-5 7H-pyrrolo[2,3-d]pyrimidine 
• 74-88-4 methyl iodide 
• 479633-63-1 4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine 
• 544-97-8 dimethyl zinc(II) 

Downstream Products

• 1195071-58-9 propane-1-sulfonic acid {2,4-difluoro-3-[hydroxy-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methyl]-phenyl}-amide 
• 941678-49-5 ruxolitinib 

Relevant articles and documents

PROCESS AND INTERMEDIATES FOR PREPARING A JAK1 INHIBITOR

The present invention is related to processes for preparing itacitinib, or a salt thereof, and related synthetic intermediates related thereto.

Method for catalytically synthesizing 7-denitrified purine compound by using iron coordination compound

The invention relates to a method for catalytically synthesizing a 7-denitrogenated purine compound by using an iron coordination compound. The method comprises the following steps: in the presence of an alkali, taking 7-denitrogenated purine and halogenated hydrocarbon as raw materials, taking an iron coordination compound containing an ortho-carborane benzoxazole structure as a catalyst, and reacting at room temperature to obtain the 6-substituted 7-denitrogenated purine compound. Compared with the prior art, the method has the advantages that the iron coordination compound containing the ortho-carborane benzoxazole structure is utilized to catalytically synthesize the 6-substituted 7-deazapurine compound, so that the compound is prepared by a one-pot method at room temperature, the use equivalent of the catalyst is low, the reaction condition is mild, the raw materials are cheap and easy to obtain, the substrate universality is high, and the yield is high.

Synthesis method of 4-methyl-7H-pyrrolo[2,3-d]pyrimidine

The invention provides a synthesis method of 4-methyl-7H-pyrrolo[2,3-d]pyrimidine, wherein the comprises the following steps: (a) reacting a substance represented by a formula (I) with a methyl Grignard reagent under the action of a catalyst to obtain a compound represented by a formula (II); and (b) carrying out dechlorination reaction on the compound represented by the formula (II) under the action of a reducing agent to obtain a compound represented by a formula (III). According to the preparation method, starting raw materials, process routes and post-treatment processes are different, the raw materials are simple and easy to obtain, the cost is low, and the preparation method is suitable for laboratory small-scale preparation and industrial production.