945992-32-5Relevant academic research and scientific papers
PEGYLATED FLUOROBENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING
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, (2012/07/14)
Pegylated fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labeled with a positron-emitting radioisotope such as 18F, can be used as radiotracers for medical imaging such as imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labeled with 123I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.
Fluorine-18-labeled benzamide analogues for imaging the σ2 receptor status of solid tumors with positron emission tomography
Tu, Zhude,Xu, Jinbin,Jones, Lynne A.,Li, Shihong,Dumstorff, Craig,Vangveravong, Suwanna,Chen, Delphine L.,Wheeler, Kenneth T.,Welch, Michael J.,Mach, Robert H.
, p. 3194 - 3204 (2008/03/12)
A series of fluorine-containing benzamide analogs was synthesized and evaluated as candidate ligands for positron emission tomography (PET) imaging of the sigma-2 (σ2) receptor status of solid tumors. Four compounds having a moderate to high af
