945997-14-8

Upstream product

• 21815-91-8 3-chlorobenzo[b]thiophen-2-carbonyl chloride 
• 1025060-99-4 trans-tert-butyl {4-[(4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate 
• 945996-93-0 trans-3-{[[4-(Boc-methyl-amino)-cyclohexyl]-(3-chlorobenzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-benzeneboronic acid 
• 623-00-7 4-bromobenzenecarbonitrile 
• 15803-59-5 (1r,4r)-N¹-methylcyclohexane-1,4-diamine 
• 566172-79-0 trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane 
• 566172-78-9 n-butyl trans-(4-aminocyclohexyl)-carbamate 
• 945996-91-8 trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzeneboronic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2615-25-0 trans-1,4-cyclohexyldiamine 

Downstream Products

• 945997-16-0 trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride 
• 945997-28-4 trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate 
• 946047-48-9 trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide 

Relevant academic research and scientific papers

Potent agonists of the Hedgehog signaling pathway

A family of biaryl substituted 1,4-diaminocyclohexanamides of 3-chlorobenzothiophene-2-carboxylic acid is reported as picomolar modulators of Hedgehog protein function. SAR for the 1,4-diaminocyclohexane group is shown to be exquisitely sensitive to subst

SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION

The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened orhedgehog activity.