946-32-7Relevant academic research and scientific papers
Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening
Yi Mok,Chadwick, James,Kellett, Katherine A.B.,Hooper, Nigel M.,Johnson, A. Peter,Fishwick, Colin W.G.
scheme or table, p. 6770 - 6774 (2010/06/12)
A novel series of isatin-based inhibitors of β-secretase (BACE-1) have been identified using a virtual high-throughput screening approach. Structure-activity relationship studies revealed structural features important for inhibition. Docking studies suggest these inhibitors may bind within the BACE-1 active site through H-bonding interactions involving the catalytic aspartate residues.
