946122-05-0

Basic information

• Product Name: 2-AMINO-4-BROMOBENZYL ALCOHOL
• Synonyms: 2-AMINO-4-BROMOBENZYL ALCOHOL;(2-AMINO-4-BROMOPHENYL)METHANOL
• CAS NO: 946122-05-0
• Molecular Formula: C₇H₈BrNO
• Molecular Weight: 202.05
• Mol File: 946122-05-0.mol

Chemical Properties

• Boiling Point: 347.821°C at 760 mmHg
• Flash Point: 164.156°C
• Appearance: /
• Density: 1.66g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.654
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.01±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-4-BROMOBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-BROMOBENZYL ALCOHOL(946122-05-0)
• EPA Substance Registry System: 2-AMINO-4-BROMOBENZYL ALCOHOL(946122-05-0)

Safety Data

• Hazardous Substances Data: 946122-05-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
2-Amino-4-Bromobenzyl Alcohol is used as a synthetic intermediate for the preparation of various organic compounds. Its presence of multiple functional groups allows for a wide range of chemical reactions, making it a valuable component in the synthesis of complex molecules.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 2-Amino-4-Bromobenzyl Alcohol is used as a building block for the development of new drugs. Its unique structure and functional groups enable the creation of potential therapeutic agents, contributing to the advancement of medicinal chemistry.
Used in Chemical Research:
2-Amino-4-Bromobenzyl Alcohol is employed as a research compound in academic and industrial laboratories. Its reactivity and structural features make it an interesting subject for studying reaction mechanisms, exploring new synthetic routes, and understanding the properties of related compounds.

InChI:InChI=1/C7H8BrNO/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4,9H2

Upstream product

• 22996-19-6 (4-bromo-2-nitrophenyl)methanol 
• 135484-83-2 2-amino-4-bromo-benzoic acid methyl ester 
• 20776-50-5 2-amino-4-bromobenzoic acid 

Downstream Products

• 1160244-51-8 3-bromo-2-phenyl-1,4-dihydro-2H-benzo[d][1,3]oxazine 
• 1203578-65-7 7-bromo-2-phenylquinoline 
• 59278-65-8 2-amino-4-bromobenzaldehyde 
• 1266322-58-0 7-bromoquinolin-3-amine 
• 1375108-29-4 7-bromo-3-fluoroquinoline 

Relevant articles and documents

Cationic Iridium-Catalyzed Asymmetric Decarbonylative Aryl Addition of Aromatic Aldehydes to Bicyclic Alkenes

We report an unprecedented catalytic protocol for the enantioselective decarbonylative transformation of aryl aldehydes. In this process, the decarbonylation of aldehydes catalyzed by chiral iridium complexes enabled the formation of asymmetric C?C bonds

Identification and preliminary structure-activity relationship studies of 1,5-dihydrobenzo[e][1,4]oxazepin-2(3h)-ones that induce differentiation of acute myeloid leukemia cells in vitro

Acute myeloid leukemia (AML) is the most aggressive type of blood cancer, and there is a continued need for new treatments that are well tolerated and improve long-term survival rates in patients. Induction of differentiation has emerged as a promising alternative to conventional cy-totoxic chemotherapy, but known agents lack efficacy in genetically distinct patient populations. Previously, we established a phenotypic screen to identify small molecules that could stimulate differentiation in a range of AML cell lines. Utilising this strategy, a 1,5-dihydrobenzo[e][1,4]oxazepin-2(3H)-one hit compound was identified. Herein, we report the hit validation in vitro, structure-ac-tivity relationship (SAR) studies and the pharmacokinetic profiles for selected compounds.

3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

Provided are cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor, compositions comprising said compounds, and uses of said compounds in the treatment or prevention of diseases in which M4 muscarinic acetylcholine receptors are involved, especially neurological and psychiatric disorders and diseases.

Pd-Catalyzed Three-Component Domino Reaction of Vinyl Benzoxazinanones for Regioselective and Stereoselective Synthesis of Allylic Sulfone-Containing Amino Acid Derivatives

A Pd-catalyzed, highly regioselective and stereoselective three-component domino allylic substitution/N-H carbene insertion reaction under mild conditions is described. This reaction demonstrates a wide substrate scope and satisfactory functional group tolerance, providing a broad range of allylic sulfone-containing amino acid derivatives. Moreover, DBU mediates highly diastereoselective cross-dehydrogenative coupling annulation of allylic sulfones without using peroxides or any metal oxidants. This developed protocol affords 7-membered ring heterocyclic compounds incorporating both sulfone-containing amino acid esters and one quaternary carbon center. Mechanistic studies indicate that an unusual umpolung of glycine occurred in this annulation.

RORGAMMA MODULATORS AND USES THEREOF

The present invention provides novel compounds of formula (la) that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.

N-heterocyclic-carbene-catalyzed synthesis of 2-aryl indoles

A convergent and efficient transition-metal-free catalytic synthesis of 2-aryl-indoles has been developed. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent generated through N-hetereocyclic carbene catalysis is central to this successful strategy. High yields and a wide scope as well as the streamlined synthesis of a kinase inhibitor are reported. Umpolung: N-heterocyclic carbene catalysis is used for the convergent and efficient transition-metal-free synthesis of 2-aryl-indoles. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent is central to this successful strategy. The reaction exhibits high yields and a wide scope, and it has been applied to a streamlined synthesis of a kinase inhibitor.

Intramolecular photoassisted cycloadditions of azaxylylenes and postphotochemical capstone modifications via suzuki coupling provide access to complex polyheterocyclic biaryls

Modular preassembly of azaxylylene photoprecursors, halogen-substituted in the aromatic ring, their intramolecular [4 + 4] or [4 + 2] cycloadditions to tethered unsaturated pendants, and subsequent postphotochemical capstone modification of the primary photoproducts via Suzuki coupling provides rapid access to diverse biaryls of unprecedented topology. This synthetic sequence allows for rapid growth of molecular complexity and is well aligned with methodology of Diversity-Oriented Synthesis.

Novel bicyclic sulfonamide derivatives which are L-CPT1 inhibitors

The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, V, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.