946160-47-0Relevant articles and documents
Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core
Clasby, Martin C.,Chackalamannil, Samuel,Czarniecki, Michael,Doller, Dario,Eagen, Keith,Greenlee, William J.,Lin, Yan,Tagat, Jayaram R.,Tsai, Hsingan,Xia, Yan,Ahn, Ho-Sam,Agans-Fantuzzi, Jacqueline,Boykow, George,Chintala, Madhu,Hsieh, Yunsheng,McPhail, Andrew T.
, p. 3647 - 3651 (2008/02/07)
The synthesis and biological activity of a novel series of thrombin receptor antagonists is described. This series of compounds showed excellent in vitro and in vivo potency. The most potent compound 40 had an IC50 of 7.6 nM and showed robust i
