94639-14-2

Basic information

• Product Name: 3-Pyridinecarbonitrile, 4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-thioxo-
• CAS NO: 94639-14-2
• Molecular Formula: C13H9ClN2S
• Molecular Weight: 260.747
• Mol File: 94639-14-2.mol

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarbonitrile, 4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile, 4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-thioxo-(94639-14-2)
• EPA Substance Registry System: 3-Pyridinecarbonitrile, 4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-thioxo-(94639-14-2)

Safety Data

• Hazardous Substances Data: 94639-14-2(Hazardous Substances Data)

Upstream product

• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 7560-44-3 methyl 4-chlorocinnamate 
• 7357-70-2 Cyanothioacetamide 
• 68029-53-8 (E)-3-(4-chlorophenyl)-2-cyanoprop-2-enethioamide 
• 67-64-1 acetone 
• 1687-47-4 propane-2,2-dithiol 
• 94639-05-1 6-Amino-4-(4-chloro-phenyl)-2,2-dimethyl-4H-[1,3]dithiine-5-carbonitrile 
• 6302-55-2 1-(4'-chlorophenyl)-1,3-butanedione 

Downstream Products

• 224320-82-5 4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-nicotinonitrile 
• 132602-46-1 3-Amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 224320-67-6 1-[3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridin-2-yl]-ethanone 
• 224320-74-5 3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid hydrazide 
• 152068-96-7 Ni((ClC₆H₄)(CH₃)C₅HNS(CN))2 
• 224320-83-6 4-(4-chloro-phenyl)-6-methyl-2-methylsulfanyl-nicotinonitrile 
• 224320-78-9 2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide 
• 224320-72-3 2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-3-oxo-butyric acid ethyl ester 
• 224320-65-4 2-(1-acetyl-2-oxo-propylsulfanyl)-4-(4-chloro-phenyl)-6-methyl-nicotinonitrile 
• 224320-63-2 4-(4-chloro-phenyl)-6-methyl-2-(2-oxo-propylsulfanyl)-nicotinonitrile 
• 224320-71-2 [4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester 
• 161976-78-9 Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-2-thioxo-2H-pyridin-1-yl]-tetrahydro-pyran-3-yl ester 
• 161976-49-4 Acetic acid (2R,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[4-(4-chloro-phenyl)-3-cyano-6-methyl-2-thioxo-2H-pyridin-1-yl]-tetrahydro-pyran-3-yl ester 
• 161976-48-3 4-(4-Chloro-phenyl)-6-methyl-2-trimethylsilanylsulfanyl-nicotinonitrile 

Relevant articles and documents

Synthesis and antimicrobial evaluation of several new pyridine, thienopyridine and pyridothienopyrazole derivatives

The reaction of thiocyanoacetamide (1) with α,β-unsaturated ketones 2a,b resulted in the formation of the corresponding newly synthesized 1 (H)pyridinethione derivatives 3a,b. Compounds 3a,b were used as synthons for the preparation of 2-S-alkyl-, 2-S-aryl-, 2-S-acetamidopyridine, thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives via a wide range of reactions with different reagents. The antimicrobial activity of some of the newly synthesized compounds was tested. Compounds 3a, 11a, 15a, and 19a,b were found to be the most active ones.

CYCLIZATION OF NITRILES. XIII. 2,2-DIALKYL-4-AMINO-6-ARYL-5-CYANO-1,3-DITHIA-4-CYCLOHEXENES IN THE SYNTHESIS OF 4-ARYL-3-CYANOPYRIDINE-2(1H)-THIONES AND THEIR HETEROCYCLIC TRANSFORMATION PRODUCTS

2,2-Dialkyl-4-amino-6-aryl-5-cyano-1,3-dithia-4-cyclohexenes were obtained in the reaction of 2,2-propane- and 2,2-butanedithiols with arylidenemalononitrile.As a result of recyclization they formed substituted 4-aryl-3-cyanopyridine-2(1H)-thiones.The synthesized compounds were used in the synthesis of various 3-aminothienopyridines and some of their derivatives.