946414-30-8

Basic information

• Product Name: (3R,6S)-N⁽¹⁾-p-methoxybenzyl-3-benzyl-5-methoxy-6-iso-propyl-3,6-dihydropyrazine-2-one
• Synonyms: (3R,6S)-N⁽¹⁾-p-methoxybenzyl-3-benzyl-5-methoxy-6-iso-propyl-3,6-dihydropyrazine-2-one
• CAS NO: 946414-30-8
• Molecular Weight: 380.487
• Mol File: 946414-30-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,6S)-N⁽¹⁾-p-methoxybenzyl-3-benzyl-5-methoxy-6-iso-propyl-3,6-dihydropyrazine-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,6S)-N⁽¹⁾-p-methoxybenzyl-3-benzyl-5-methoxy-6-iso-propyl-3,6-dihydropyrazine-2-one(946414-30-8)
• EPA Substance Registry System: (3R,6S)-N⁽¹⁾-p-methoxybenzyl-3-benzyl-5-methoxy-6-iso-propyl-3,6-dihydropyrazine-2-one(946414-30-8)

Safety Data

• Hazardous Substances Data: 946414-30-8(Hazardous Substances Data)

Upstream product

• 946414-23-9 (S)-N⁽¹⁾-p-methoxybenzyl-5-methoxy-6-iso-propyl-3,6-dihydropyrazine-2-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 35590-87-5 (3S,6R)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione 
• 946414-64-8 (3R,6S)-N⁽¹⁾-p-methoxybenzyl-3-benzyl-3,6-di-iso-propyl-5-methoxy-3,6-dihydropyrazine-2-one 
• 946414-65-9 (3S,6S)-N⁽¹⁾-p-methoxybenzyl-3-benzyl-3,6-di-iso-propyl-5-methoxy-3,6-dihydropyrazine-2-one 
• 946414-60-4 (3R,6S)-N⁽¹⁾-p-methoxybenzyl-3-benzyl-3-methyl-5-methoxy-6-iso-propyl-3,6-dihydropyrazine-2-one 

Relevant articles and documents

Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates

Sequential enolate alkylations of (S)-N(1)-methyl-5-methoxy-6-isopropyl-3, 6-dihydropyrazin-2-one and (S)-N(1)-p-methoxybenzyl-5-methoxy-6-isopropyl-3,6- dihydropyrazin-2-one proceed with excellent levels of diastereoselectivity (>90% de) affording quaternary α-amino acids in high enantiomeric excess (>98% ee) after deprotection and hydrolysis. This journal is The Royal Society of Chemistry.