946424-26-6

Basic information

• Product Name: 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-diacetate
• Synonyms: 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-diacetate
• CAS NO: 946424-26-6
• Molecular Weight: 252.172
• Mol File: 946424-26-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-diacetate(946424-26-6)
• EPA Substance Registry System: 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-diacetate(946424-26-6)

Safety Data

• Hazardous Substances Data: 946424-26-6(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 95058-77-8 2-deoxy-2,2-difluoro-1-carbonylribose 
• 75-36-5 acetyl chloride 

Relevant articles and documents

Process for Preparing Gemcitabine and Associated Intermediates

The present invention provides processes for preparing novel chemical substances that are useful as intermediates in the preparation of gemcitabine and processes for preparing gemcitabine therewith. Exemplary intermediates include mixtures of D-erythro and D-threo (3R- and 3S-) isomers of 3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionic acid salts. Also provided is a novel process for selectively isolating the D-erythro and D-threo isomers of the said salts in purities of at least about 95%, and processes of using them for preparing nucleoside analogs such as, e.g., gemcitabine and intermediates and analogs thereof.