946435-59-2Relevant academic research and scientific papers
Synthesis of dihydrooxepin models related to the antitumor antibiotic MPC1001
Peng, Jianbiao,Clive, Derrick L. J.
, p. 2939 - 2941 (2008/02/07)
4-Hydroxy-L-proline was converted into the tetrahydrooxepino[4,3-b]pyrrole ring system characteristic of the potent antitumor agent MPC1001. Key steps were regioselective formation of a vinylogous amide by use of Bredereck's reagent and acid-induced cyclization of an alcohol onto the carbon-carbon double bond of that amide by addition-elimination to generate the seven-membered oxacyclic subunit. American Chemical Society.
