946518-61-2

Basic information

• Product Name: LY2409881
• Synonyms: 2-[5-Chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropylbenzo[b]thiophene-4-carboxamide;2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide
• CAS NO: 946518-61-2
• Molecular Formula: C24H29ClN6OS
• Molecular Weight: 485.04466
• EINECS: -0
• Mol File: 946518-61-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: LY2409881(CAS DataBase Reference)
• NIST Chemistry Reference: LY2409881(946518-61-2)
• EPA Substance Registry System: LY2409881(946518-61-2)

Safety Data

• Hazardous Substances Data: 946518-61-2(Hazardous Substances Data)

Usage

Description

LY2409881 is a novel, potent, and selective cannabinoid receptor type 1 (CB1) antagonist, primarily developed for the treatment of obesity and metabolic disorders. It functions by blocking the activity of the CB1 receptor, which plays a crucial role in regulating food intake and energy metabolism. By inhibiting this receptor, LY2409881 effectively reduces appetite and promotes weight loss. Although its development was halted due to concerns about potential psychiatric side effects, it remains a significant research tool for understanding the endocannabinoid system's role in energy balance and metabolic function.

Uses

Used in Pharmaceutical Industry:
LY2409881 is used as a therapeutic agent for the treatment of obesity and metabolic disorders. It is employed for its ability to reduce appetite and promote weight loss by blocking the CB1 receptor, which regulates food intake and energy metabolism.
Used in Research Applications:
LY2409881 is used as a research tool for studying the endocannabinoid system's role in regulating energy balance and metabolic function. Its selective antagonism of the CB1 receptor provides valuable insights into the mechanisms of appetite regulation and energy metabolism, contributing to the development of potential new treatments for obesity and related metabolic disorders.

Upstream product

• 4572-03-6 3-(N-methylpiperazino)propylamine 
• 946518-07-6 2-(2,5-dichloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide 

Downstream Products

• 946518-60-1 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide trihydrochloride 

Relevant articles and documents

[4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases

The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.