946523-05-3Relevant academic research and scientific papers
Amide bond formation with a new fluorous carbodiimide: Separation by reverse fluorous solid-phase extraction
Del Pozo, Carlos,Keller, Adam I.,Nagashima, Tadamichi,Curran, Dennis P.
, p. 4167 - 4170 (2008/02/12)
A new fluorous carbodiimide is introduced along with a convenient procedure for amide coupling reactions. Reactions of acids and amines under standard conditions for carbodiimide couplings, followed by simple reverse fluorous solid-phase extraction (FSPE) over standard silica gel, provide the target amide products in good yields and purities. The use of HFE-7100 as a fluorous solvent is crucial for the success of the reverse FSPE.
From tyrosine to glycine: Synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor
Romagnoli, Romeo,Baraldi, Pier Giovanni,Carrion, Maria Dora,Cara, Carlota Lopez,Preti, Delia,Cruz-Lopez, Olga,Tabrizi, Mojgan Aghazadeh,Moorman, Allan R.,Gessi, Stefania,Fogli, Eleonora,Sacchetto, Valeria,Borea, Pier Andrea
, p. 3706 - 3715 (2008/02/09)
The characterization of the native and recombinant P2X7 receptor continues to be hindered by the lack of specific and subtype-selective antagonists with a "druglike" profile. However, a tyrosine derivative named KN-62 exhibits selective P2Xsub
