946529-21-1Relevant articles and documents
Synthesis and biological evaluation of N-pyrazolyl-N′-alkyl/benzyl/ phenylureas: A new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis
Bruno, Olga,Brullo, Chiara,Bondavalli, Francesco,Schenone, Silvia,Ranise, Angelo,Arduino, Nicoletta,Bertolotto, Maria B.,Montecucco, Fabrizio,Ottonello, Luciano,Dallegri, Franco,Tognolini, Massimiliano,Ballabeni, Vigilio,Bertoni, Simona,Barocelli, Elisabetta
, p. 3618 - 3626 (2007)
Neutrophils chemotaxis is a complex multistep process that, if upregulated, causes acute inflammation and a number of autoimmune diseases. We report here the synthesis of a new N-(4-substituted)pyrazolyl-N′-alkyl/benzyl/ phenylureas that are potent inhibi