946572-15-2Relevant academic research and scientific papers
2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors
Muraglia, Ester,Altamura, Sergio,Branca, Danila,Cecchetti, Ottavia,Ferrigno, Federica,Orsale, Maria Vittoria,Palumbi, Maria Cecilia,Rowley, Michael,Scarpelli, Rita,Steinkuehler, Christian,Jones, Philip
experimental part, p. 6083 - 6087 (2009/07/18)
Trifluoroacetylthiophene carboxamides have recently been reported to be class II HDAC inhibitors, with moderate selectivity. Exploration of replacements for the carboxamide with bioisosteric pentatomic heteroaromatic like 1,3,4-oxadiazoles, 1,2,4-oxadiazo
THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS
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Page/Page column 44-45, (2008/06/13)
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative dise
