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1-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-cyclopentylurea is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

946593-15-3

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946593-15-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 946593-15-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,6,5,9 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 946593-15:
(8*9)+(7*4)+(6*6)+(5*5)+(4*9)+(3*3)+(2*1)+(1*5)=213
213 % 10 = 3
So 946593-15-3 is a valid CAS Registry Number.

946593-15-3Downstream Products

946593-15-3Relevant academic research and scientific papers

Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis

Santella, Joseph B.,Gardner, Daniel S.,Duncia, John V.,Wu, Hong,Dhar, Murali,Cavallaro, Cullen,Tebben, Andrew J.,Carter, Percy H.,Barrish, Joel C.,Yarde, Melissa,Briceno, Stephanie W.,Cvijic, Mary Ellen,Grafstrom, R. Robert,Liu, Richard,Patel, Sima R.,Watson, Andrew J.,Yang, Guchen,Rose, Anne V.,Vickery, Rodney D.,Caceres-Cortes, Janet,Caporuscio, Christian,Camac, Daniel M.,Khan, Javed A.,An, Yongmi,Foster, William R.,Davies, Paul,Hynes, John

, p. 7550 - 7564 (2015/02/18)

High-affinity, functionally potent, urea-based antagonists of CCR1 have been discovered. Modulation of PXR transactivation has revealed the selective and orally bioavailable CCR1 antagonist BMS-817399 (29), which entered clinical trials for the treatment of rheumatoid arthritis.

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