690660-22-1

Upstream product

• 690660-21-0 4-(4-chloro-phenyl)-3,3-dimethyl-piperidin-4-ol 
• 324769-06-4 tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate 
• 475085-56-4 4-(4-chloro-phenyl)-4-hydroxy-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 34737-89-8 1-Benzyl-3-methyl-4-piperidon 
• 173186-91-9 N-benzyl-3,3-dimethylpiperidine-4-one 
• 849106-47-4 4-(4-chloro-phenyl)-3,3-dimethyl-piperidin-4-ol L-(+) tartrate salt 

Downstream Products

• 690660-23-2 S-1-(5-{3-[4-(4-chloro-phenyl)-4-hydroxy-3,3-dimethyl-piperidin-1-yl]-propylidene}-5,11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-7-yl)-ethanone 
• 946594-20-3 tert-butyl (R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate 
• 1108154-38-6 N-(4-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-4-oxobutan-2-yl)benzamide 
• 1108154-39-7 (S)-tert-butyl 4-(4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-methyl-4-oxobutan-2-ylcarbamate 
• 1108154-48-8 (S)-tert-butyl 4-(2-(4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-2-oxoethyl)tetrahydro-2H-pyran-4-ylcarbamate 
• 1108154-54-6 2-(trimethylsilyl)ethyl (S)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)-3-methylbutylcarbamate 
• 946590-47-2 C₂₅H₃₂ClN₃O₃ 
• 946585-01-9 C₂₅H₃₀Cl₂N₂O₃ 
• 946584-96-9 C₂₅H₃₀Cl₂N₂O₃ 
• 1443511-42-9 (S)-1-tert-butyl 2-((1R,3R)-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamoyl)cyclopentyl) pyrrolidine-1,2-dicarboxylate 
• 946583-44-4 C₂₅H₃₀Cl₂N₂O₃ 
• 946585-20-2 C₂₅H₃₂ClN₃O₅S 
• 946594-71-4 C₂₆H₃₁ClN₂O₅ 
• 946585-00-8 C₂₆H₃₁ClN₂O₅ 

Relevant academic research and scientific papers

CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

The discovery of BMS-457, a potent and selective CCR1 antagonist

A series of compounds which exhibited good human CCR1 binding and functional potency was modified resulting in the discovery of a novel series of high affinity, functionally potent antagonists of the CCR1 receptor. Issues of PXR activity, ion-channel pote

PRODRUGS OF A PIPERIDINYL DERIVATIVE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present application describes prodrugs of the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well a

PIPERIDINYL DERIVATIVE AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY

The present application describes the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune

CCR1 antagonists and methods of use therefor

The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compound