946604-99-5

Usage

Uses

Used in Organic Synthesis:
5-Bromo-3-tert-butoxycarbonylamino-thiophene-2-carboxylic acid methyl ester is used as a building block in organic synthesis for the synthesis of various biologically active compounds.
Used in Pharmaceutical Research:
In Pharmaceutical Research, 5-Bromo-3-tert-butoxycarbonylamino-thiophene-2-carboxylic acid methyl ester is used as a precursor in the preparation of thieno[3,2-b]pyrrole derivatives, which have potential applications as antitumor and antiviral agents.
Used in Pharmaceutical Industry:
5-Bromo-3-tert-butoxycarbonylamino-thiophene-2-carboxylic acid methyl ester is used in the pharmaceutical industry for the development of new drugs with therapeutic value.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 107818-55-3 3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester 
• 149587-72-4 3-(tert-butoxycarboxamido)thiophen-2-formic acid methyl ester 

Downstream Products

• 494833-79-3 3-amino-5-bromothiophene-2-carboxyamide 
• 1309853-22-2 3-[(2,4-dichloro-benzoyl)-(2-methoxy-ethyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylic acid 

Relevant academic research and scientific papers

THIENOAZEPINE IMMUNOCONJUGATES, AND USES THEREOF

The invention provides immunoconjugates of Formula I comprising an antibody linked by conjugation to one or more thienoazepine derivatives. The invention also provides thienoazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.

MACROMOLECULE-SUPPORTED THIENOAZEPINE COMPOUNDS, AND USES THEREOF

The invention provides macromolecule-supported compounds of Formula I comprising a macromolecular support linked by conjugation to one or more thienoazepine derivatives. The invention also provides thienoazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the macromolecule-supported compounds through a linker or linking moiety. The invention further provides methods of treating cancer with the macromolecule-supported compounds.

Compound and method for preparing substituted [5,6]cyclo-4(3H)-pyrimidinone compound by using same

The invention provides a compound and a method for preparing a substituted [5,6]cyclo-4-(3H)-pyrimidinone compound by using the same. The compound has a structure shown as a formula II, and the compound with the structure shown as the formula II can be used for preparing a substituted [5,6]cyclo-4-(3H)-pyrimidinone compound or a pharmaceutically acceptable salt of the substituted [5,6]cyclo-4-(3H)-pyrimidinone compound. According to the preparation method of the substituted [5,6]cyclo-4-(3H)-pyrimidinone compound, cyclization reaction under a strong alkaline condition is effectively avoided, the synthesis yield is high, and the process is stable.

SUBSTITUTED [5,6]CYCLIC-4(3H)-PYRIMIDINONES AS ANTICANCER AGENTS

The present invention relates to novel substituted [5,6]cyclic-4(3H)-pyrimidinone compounds of formula (I) and their preparation methods. (I) In particular, the present invention relates to novel substituted [5,6]cyclic-4(3H)- pyrimidinone compounds useful as inhibitors of protein kinases, specifically CDC7 (cell division cycle 7) inhibitors.

NOVEL AZACYCLY-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

The invention relates to azacyclyl-substituted arylthienopyrimidinones and their derivatives of formula (I), and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the azacyclyl-substituted aryithienopyrimidinones of the invention and their derivatives as MCH antagonists.

NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

The invention relates to amino alcohol-substituted arylthienopyrimidinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one amino alcohol-su

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides

The discovery of a novel class of HCV NS5B polymerase inhibitors, 3-arylsulfonylamino-5-phenyl-thiophene-2-carboxylic acids is described. SAR studies have yielded several potent inhibitors of HCV polymerase as well as of HCV subgenomic RNA replication in