946718-12-3Relevant academic research and scientific papers
PHARMACEUTICAL COMPOSITIONS
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Page/Page column 19, (2008/06/13)
This invention provides pharmaceutical compositions comprising therapeutically effective amounts of a monoamine reuptake inhibitor and an SK inhibitor. In another aspect the invention provides novel benzoimidazole derivatives for use according to the inve
Synthesis and structure-activity relationship of new piperidinyl and piperazinyl derivatives as antiallergics
Orjales,Bordell,Rubio
, p. 707 - 718 (2007/10/02)
A series of piperazinebenzothiazoles 3-5, piperazinebenzimidazoles 6-12, piperidinobenzothiazoles 14-45, piperidinobenzoxazoles 46-52 and piperidinobenzimidazoles 53-129 has been synthesized and their antiallergic activity evaluated by means of the passive cutaneous anaphylaxis (PCA) assay. Structure-activity relationships are discussed and related to classical antihistaminics. Piperidino derivatives with an aryl group linked to the nitrogen atom by an ethyl chain are the most active compounds, with ID50 1 mg/kg po. Some of these compounds are more potent antiallergics than astemizole and terfenadine.
