57159-81-6

Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole,2-(methylsulfonyl)-(9CI) is used as an intermediate in the synthesis of other organic compounds for its unique chemical properties. It serves as a building block in the development of drugs, potentially contributing to the creation of new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 1H-Benzimidazole,2-(methylsulfonyl)-(9CI) is utilized as a component in the formulation of pesticides or other agricultural chemicals, leveraging its chemical characteristics to enhance the effectiveness of these products.
Used in Materials Science:
1H-Benzimidazole,2-(methylsulfonyl)-(9CI) is employed in materials science as a component in the development of new materials, such as dyes or other specialty chemicals, where its sulfonyl group may impart specific properties beneficial to the final product's performance.
It is crucial to handle 1H-Benzimidazole,2-(methylsulfonyl)-(9CI) with care and follow safety guidelines to ensure safe usage in all applications.

InChI:InChI=1/C8H8N2O2S/c1-13(11,12)8-9-6-4-2-3-5-7(6)10-8/h2-5H,1H3,(H,9,10)

Upstream product

• 7152-24-1 2-methylsulfanylbenzimidazole 
• 134469-07-1 Benzimidazol-2-thiol 
• 583-39-1 2,3-dihydrobenzimidazol-2-thione 
• 10213-10-2 sodium tungstate (VI) dihydrate 
• 98639-91-9 1-H-1,3-benzimidazol-2-yl methyl sulfoxide 

Downstream Products

• 61078-14-6 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole 
• 100969-46-8 1-benzyl-2-methanesulfonyl-1H-benzimidazole 
• 946718-12-3 2-<(4-diphenylmethyl)-1-piperazinyl>-1H-benzimidazole 
• 4929-52-6 2-((4-methoxyphenyl)thio)-1H-benzo[d]imidazole 
• 1018987-23-9 C₁₃H₉ClN₂O 
• 1018987-22-8 C₁₉H₁₄N₂O 
• 1018987-20-6 C₁₃H₁₀N₂OS 
• 1018987-18-2 2-((3-fluorophenyl)thio)-1H-benzo[d]imidazole 
• 1018987-24-0 C₁₄H₉F₃N₂O 
• 1018987-29-5 C₁₃H₁₁N₃O 
• 446845-17-6 C₁₃H₁₁N₃O 
• 24752-30-5 N-(4-chlorophenyl)-1H-benzo[d]imidazol-2-amine 
• 2360-29-4 2-(phenylsulfanyl)-1H-benzimidazole 
• 1018987-21-7 C₁₄H₁₂N₂O 

Relevant academic research and scientific papers

Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y

A metal-free α-aminomethylation of heteroaryls promoted by eosin Y under green light irradiation is reported. A large variety of α-trimethylsilylamines as precursor of α-aminomethyl radical species were engaged to functionalize sulfonyl-heteroaryls following a Homolytic Aromatic Substitution (HAS) pathway. This method has provided a range of α-aminoheteroaryl compounds including a functionalized natural product. The mechanism of this late-stage functionalization of aryls was investigated and suggests the formation of a sulfonyl radical intermediate over a reductive quenching cycle.

An environmentally benign and selective electrochemical oxidation of sulfides and thiols in a continuous-flow microreactor

A practical and environmentally benign electrochemical oxidation of thioethers and thiols in a commercially-available continuous-flow microreactor is presented. Water is used as the source of oxygen to enable the oxidation process. The oxidation reaction utilizes the same reagents in all scenarios and the selectivity is solely governed by the applied potential. The procedure exhibits a broad scope and good functional group compatibility providing access to various sulfoxides (15 examples), sulfones (15 examples) and disulfides (6 examples). The use of continuous flow allows the optimal reaction parameters (e.g. residence time, applied voltage) to be rapidly assessed, to avoid mass- and heat-transfer limitations and to scale the electrochemistry.

Polyoxomolybdate-Calix[4]arene Hybrid: A Catalyst for Sulfoxidation Reactions with Hydrogen Peroxide

An easily accessible polyoxomolybdate-calix[4]arene hybrid 1 has been synthesized and applied as a heterogeneous catalyst in the sulfoxidation of thioethers to sulfoxides and to sulfones under strictly stoichiometric amounts of 30% H2O2 in CH3CN as the solvent. This study represents the first promising example of successful employment of calixarenes-polyoxometalate (POM) hybrid materials in the area of catalytic oxidations.

Rapid, stable, chemoselective labeling of thiols with Julia- Kocienski-like reagents: A serum-stable alternative to maleimide-based protein conjugation

Exquisite chemoselectivity for cysteine has been found for methylsulfonylphenyloxadiazole compounds under various buffer conditions. Furthermore, the resulting protein conjugates have superior stability to cysteine-maleimide conjugates in human plasma (HS

TiCl4 hiocarbonyls and oxidation of sulfides in the presence of H2O2

H2O2 in combination with TiCl4 proved to be a highly reactive reagent system for the desulfurization of thioamide and thioketone derivatives in excellent yields and short reaction times with high purity. Sulfides were also found to undergo oxidation to sulfones under similar reaction conditions. In most cases, these reactions are highly selective, simple, and clean, affording products in high yields and purity.

Cyanuric chloride as promoter for the oxidation of sulfides and deoxygenation of sulfoxides

This Letter discusses the use of cyanuric chloride as an efficient promoter for the chemoselective oxidation of sulfides to the corresponding sulfones in the presence of H2O2 as the terminal oxidant. Sulfoxides were also found to undergo deoxygenation to sulfides with cyanuric chloride and potassium iodide system. The reaction is broad in scope and easy to perform.

Synthesis and structure-activity relationship of new piperidinyl and piperazinyl derivatives as antiallergics

A series of piperazinebenzothiazoles 3-5, piperazinebenzimidazoles 6-12, piperidinobenzothiazoles 14-45, piperidinobenzoxazoles 46-52 and piperidinobenzimidazoles 53-129 has been synthesized and their antiallergic activity evaluated by means of the passive cutaneous anaphylaxis (PCA) assay. Structure-activity relationships are discussed and related to classical antihistaminics. Piperidino derivatives with an aryl group linked to the nitrogen atom by an ethyl chain are the most active compounds, with ID50 1 mg/kg po. Some of these compounds are more potent antiallergics than astemizole and terfenadine.

Water-soluble benzimidazolotriazole derivative or salt thereof

A water-soluble benzimidazolotriazole derivative of formula (I): STR1 wherein X represents a sulfo group, a sulfonato group or a --N--(R)2 group, R represents an alkyl group having 6 carbon atoms or less; and n represents a natural number of 8 or less. The benzimidazolotriazole derivative of formula (I) may form a salt with an organic or inorganic acid.

Substituted arylsulfonamides and benzamides

This invention relates to substituted arylsulfonamides and benzamides possessing aniarrhythmic activity, to pharmaceutical compositions and to methods for production thereof.