946832-64-0

Basic information

• Product Name: 4,2',3'-trimethyl-4'-(o-fluorobenzyl)purpurogallin
• Synonyms: 4,2',3'-trimethyl-4'-(o-fluorobenzyl)purpurogallin
• CAS NO: 946832-64-0
• Molecular Weight: 370.377
• Mol File: 946832-64-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4,2',3'-trimethyl-4'-(o-fluorobenzyl)purpurogallin(CAS DataBase Reference)
• NIST Chemistry Reference: 4,2',3'-trimethyl-4'-(o-fluorobenzyl)purpurogallin(946832-64-0)
• EPA Substance Registry System: 4,2',3'-trimethyl-4'-(o-fluorobenzyl)purpurogallin(946832-64-0)

Safety Data

• Hazardous Substances Data: 946832-64-0(Hazardous Substances Data)

Upstream product

• 15795-64-9 4-hydroxy-2,3,6-trimethoxy-5H-benzo[7]annulen-5-one 
• 345-35-7 2-fluorobenzyl chloride 

Downstream Products

• 1425037-06-4 C₂₇H₂₀FNO₆ 

Relevant articles and documents

Synthesis and evaluation as potential anticancer agents of novel tetracyclic indenoquinoline derivatives

We report the synthesis and evaluation as potential anticancer agents of a series of tetracyclic indenoquinolines. The compounds, which are obtained through the photoisomerization of Diels-Alder adducts formed between purpurogallin derivatives and nitrosobenzene, have in vitro antiproliferative activities in the μM to nM range against breast (MCF-7), lung epithelial (A-549), and cervical (HeLa) adenocarcinoma cells. The cytotoxicities of several of the novel tetracycles are comparable to or better than that of camptothecin. A strong correlation between the activity of the compounds and their aromaticity and planarity was observed, suggesting a mode of action similar to that of topoisomerase poisons.