94688-14-9Relevant academic research and scientific papers
A biocompatible inverse electron demand Diels-Alder reaction of aldehyde and tetrazine promoted by proline
Lai, Shuiqin,Mao, Wuyu,Song, Heng,Xia, Lingying,Xie, Hexin
supporting information, p. 8194 - 8197 (2016/10/11)
A proline-mediated inverse electron demand Diels-Alder reaction of aldehyde and tetrazine is disclosed. This biocompatible reaction is very fast (with apparent k2 up to 13.8 M-1 s-1) and has been used in the labeling of bovine serum albumin in aqueous medium.
Pyridazines in crystal engineering. A systematic evaluation of the role of isomerism and steric factors in determining crystal packing and nano/microcrystal morphologies
Varughese, Sunil,Draper, Sylvia M.
experimental part, p. 2571 - 2580 (2011/11/14)
The present study focuses on understanding hydrogen bond patterns in a series of variably substituted pyridyl-pyridazines as a function of positional isomerism and steric factors. A relatively uncommon multiple hydrogen bond acceptor nature of pyridazine
Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines
Xie, Hexin,Zu, Liansuo,Oueis, Hanine R.,Li, Hao,Wang, Jian,Wang, Wei
supporting information; experimental part, p. 1923 - 1926 (2009/04/08)
An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields.
