947303-87-9 Usage
Uses
Used in Pharmaceutical Industry:
PF 429242 is used as a therapeutic agent for the treatment of pancreatic cancer. It has been shown to decrease pancreatic cancer cell viability and proliferation by inhibiting SKI-1/S1P protease and SREBP1. This dual inhibition mechanism makes PF 429242 a potential candidate for the development of novel cancer therapies.
Used in Cancer Research:
PF 429242 is used as a research tool in cancer biology to study the role of SKI-1/S1P protease and SREBP1 in pancreatic cancer progression. Its ability to inhibit these targets provides valuable insights into the molecular mechanisms underlying cancer development and may lead to the identification of new therapeutic targets.
Used in Drug Development:
PF 429242 is used in the development of new drugs for the treatment of pancreatic cancer and potentially other cancer types. Its unique mechanism of action and promising preclinical results make it a valuable compound for further research and development in the pharmaceutical industry.
Biochem/physiol Actions
PF-429242 is a potent inhibitor of S1P (cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease) that reduces expression levels of hepatic SREBP target genes and lower rates of cholesterol and fatty acid synthesis in mice. PF-429242 is a potent antiviral agent against prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV in cultured cells. PF-429242 efficiently prevented the processing of GPC from the LCMV and LASV. PF-429242 is expected to be active against CCHFV.
Check Digit Verification of cas no
The CAS Registry Mumber 947303-87-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,7,3,0 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 947303-87:
(8*9)+(7*4)+(6*7)+(5*3)+(4*0)+(3*3)+(2*8)+(1*7)=189
189 % 10 = 9
So 947303-87-9 is a valid CAS Registry Number.
947303-87-9Relevant academic research and scientific papers
Aminopyrrolidineamide inhibitors of site-1 protease
Hay, Bruce A.,Abrams, Barbara,Zumbrunn, Allice Y.,Valentine, James J.,Warren, Laurie C.,Petras, Stephen F.,Shelly, Lorraine D.,Xia, Angela,Varghese, Alison H.,Hawkins, Julie L.,Van Camp, Jennifer A.,Robbins, Michael D.,Landschulz, Katherine,Harwood Jr., H. James
, p. 4411 - 4414 (2008/02/10)
The discovery and efficacy of a series of potent aminopyrrolidineamide-based inhibitors of sterol regulatory element binding protein site-1 protease is described.
