94741-69-2

Basic information

• Product Name: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE
• Synonyms: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE;4-AMINO-2-CHLORO-5-PYRIMIDINECARBONITRILE;BUTTPARK 60\40-60;4-AMINO-2-CHLOROPYRIMIDINE-5-CARBOXNITR&;4-Amino-2-chloropyrimidine-5-carbonitrile ,97%;4-Amino-2-chloropyrimidine-5-carbonitrile , Tech.;5-PyriMidinecarbonitrile, 4-aMino-2-chloro-
• CAS NO: 94741-69-2
• Molecular Formula: C₅H₃ClN₄
• Molecular Weight: 154.56
• Product Categories: Pyrimidine;Heterocyclic Compounds;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Building Blocks;C4 to C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 94741-69-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 200 °C (dec.)(lit.)
• Boiling Point: 435.047 °C at 760 mmHg
• Flash Point: 216.909 °C
• Appearance: /Powder or Flakes
• Density: 1.538 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMF, DMSO, Methanol, Water
• PKA: -0.68±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE(94741-69-2)
• EPA Substance Registry System: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE(94741-69-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-36/37/39
• RIDADR: UN3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 94741-69-2(Hazardous Substances Data)

Usage

Uses

4-Amino-2-chloropyrimidine-5-carbonitrile is a potential substituent in the synthesis of anti-anxiety, anti-depressant and anti-psychotic agents.

Upstream product

• 3177-24-0 2,4-dichloropyrimidine-5-carbonitrile 
• 113411-64-6 3-Cyanamino-2-cyanopropenenitrile sodium salt 

Downstream Products

• 94742-00-4 4-Amino-2-ethoxy-pyrimidine-5-carbonitrile 
• 6964-55-2 4-amino-2-methoxy-pyrimidine-5-carbonitrile 
• 113411-73-7 Methyl 2<4-(4-amino-5-cyanopyrimidyl-2-oxy)phenoxy>propionate 
• 94741-65-8 4-Amino-2-hexadecyloxy-pyrimidine-5-carbonitrile 
• 94741-64-7 4-Amino-2-decyloxy-pyrimidine-5-carbonitrile 
• 78318-43-1 4-Amino-2-morpholino-pyrimidin-5-carbonitril 
• 90973-23-2 4-amino-2-piperidin-1-yl-pyrimidine-5-carbonitrile 
• 113411-65-7 4-Amino-2-phenoxy-pyrimidine-5-carbonitrile 
• 113411-66-8 4-Amino-2-(4-methoxy-phenoxy)-pyrimidine-5-carbonitrile 

Relevant articles and documents

PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS PI3K INHIBITORS

Compounds (I) and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.

A Convenient Synthesis of 2-Substituted 4-Amino-5-pyrimidinecarbonitriles

Synthesis of the novel 2-halogenated 4-amino-5-pyrimidinecarbonitriles 3a,b starting from ethoxymethylenemalononitrile 1 and cyanamide is described.Nucleophilic substitution of the reactive halogen atom leads to the derivatives 5a-g,6 and 7a-h.