78318-43-1Relevant articles and documents
SUSTITUTED ( HETEROARYLMETHYL ) THIOHYDANTOINS AS ANTICANCER DRUGS
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Page/Page column 52, (2011/04/18)
The invention relates to substituted (heteroarylmethyl) thiohydantoin compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, and their use for the preparation of medicaments for the treatment and/or prophylaxis of disorders, in particular of prostate cancer.
A Convenient Synthesis of 2-Substituted 4-Amino-5-pyrimidinecarbonitriles
Schmidt, Hans-Werner,Koitz, Gerald,Junek, Hans
, p. 1305 - 1307 (2007/10/02)
Synthesis of the novel 2-halogenated 4-amino-5-pyrimidinecarbonitriles 3a,b starting from ethoxymethylenemalononitrile 1 and cyanamide is described.Nucleophilic substitution of the reactive halogen atom leads to the derivatives 5a-g,6 and 7a-h.