947530-26-9Relevant academic research and scientific papers
Access to 2,6-disubstituted piperidines: Control of the diastereoselectivity, scope, and limitations. applications to the stereoselective synthesis of (-)-solenopsine A and alkaloid (+)-241D
Abrunhosa-Thomas, Isabelle,Plas, Aurelie,Vogrig, Alexandre,Kandepedu, Nishanth,Chalard, Pierre,Troin, Yves
, p. 2511 - 2526 (2013/04/24)
Scope and limitations in the diastereoselective preparation of 2,6-cis or 2,6-trans disubstituted piperidines are described, through intramolecular reaction of chiral β′-carbamate-α,β-unsaturated ketone. This methodology has been applied to the total synthesis of a few well chosen examples, such as (-)-solenopsine A and alkaloid (+)-241D.
Diastereoselective synthesis of 2-monosubstituted and 2,6-disubstituted piperidines
Abrunhosa-Thomas, Isabelle,Roy, Olivier,Barra, Marielle,Besset, Tatiana,Chalard, Pierre,Troin, Yves
, p. 1613 - 1615 (2008/02/05)
An intramolecular Michael-type reaction, involving β′-amino- α,β-unsaturated ketone is used to prepare 2-mono- and 2,6-disusbtituted piperidines in a diastereoselective manner. This strategy allows an easy access to 2,6-trans-piperidine, starting from eit
