947538-46-7Relevant academic research and scientific papers
Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors
Suzuki, Takayoshi,Hisakawa, Shinya,Itoh, Yukihiro,Suzuki, Nobuaki,Takahashi, Katsumasa,Kawahata, Masatoshi,Yamaguchi, Kentaro,Nakagawa, Hidehiko,Miyata, Naoki
, p. 4208 - 4212 (2008/02/12)
Aiming to develop selective anticancer drugs, we designed and synthesized three disulfides bearing a folic acid moiety as candidate folate receptor (FR)-targeted prodrugs of thiolate histone deacetylase inhibitors. Among them, compound 1 displayed growth-inhibitory activity toward folate receptor-positive MCF-7 breast cancer cells. The activity of 1 was significantly reduced by free folic acid, suggesting that cellular uptake of 1 is mediated by FR.
