84793-07-7

Basic information

• Product Name: Fmoc-L-Glutamic acid 1-tert-butyl ester
• Synonyms: L-GLUTAMIC ACID, N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-, 1-(1,1-DIMETHYLETHYL) ESTER;N-α-Fmoc-L-glutamic acid α-tert butyl ester;Fmoc glutamic acid butyl ester;(S)-4-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-5-(tert-butoxy)-5-oxopentanoic acid;N-FMoc-L-glutaMic acid 1-tert-butyl ester;Fmoc-L-glutamic acid α-tert-butyl ester≥ 98% (HPLC, Chiral purity);N-FMOC-L-GLUTAMIC ACID-1-T-BUTYL ESTER;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-GLUTAMIC ACID ALPHA-T-BUTYL ESTER
• CAS NO: 84793-07-7
• Molecular Formula: C₂₄H₂₇NO₆
• Molecular Weight: 425.47
• Product Categories: Glutamic acid [Glu, E]
• Mol File: 84793-07-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 78-80 °C
• Boiling Point: 638.1 °C at 760 mmHg
• Flash Point: 339.7 °C
• Appearance: /
• Density: 1.232 g/cm³
• Storage Temp.: Store at RT.
• PKA: 4.46±0.10(Predicted)
• CAS DataBase Reference: Fmoc-L-Glutamic acid 1-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-L-Glutamic acid 1-tert-butyl ester(84793-07-7)
• EPA Substance Registry System: Fmoc-L-Glutamic acid 1-tert-butyl ester(84793-07-7)

Safety Data

• Hazardous Substances Data: 84793-07-7(Hazardous Substances Data)

Upstream product

• 45120-30-7 L-glutamic acid α-tert-butyl ester 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 56-86-0 L-glutamic acid 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 115-11-7 isobutene 
• 157108-58-2 (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanedioic acid 5-benzyl ester 1-tert-butyl ester 
• 123639-61-2 Fmoc-L-glutamic acid-g-benzyl ester 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Downstream Products

• 105644-04-0 γ-L-glutamyl-γ-L-glutamyl-L-cysteinylglycine 
• 1408065-27-9 C₃₉H₄₂FN₅O₆ 
• 1408065-76-8 Fmoc-Glu-OtBu 
• 1609283-71-7 C₁₈H₂₆N₂O₅ 
• 1609283-72-8 C₃₄H₅₆N₂O₆ 
• 1609283-70-6 C₃₃H₃₆N₂O₇ 

Relevant articles and documents

Preparation method of N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid

The invention provides a preparation method of N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid. The preparation method mainly solves the technical problems of complexity, long period, high cost, and low yield of an original process, and comprises the following steps: (1) preparing N-fluorenylmethoxycarbonyl-L-glutamic acid; (2) preparing N-fluorenylmethoxycarbonyl-L-glutamic acid-1-benzyl ester; (3) preparing S-triphenylmethyl cysteamine; (4) preparing N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid-alpha-benzyl ester; and (5) preparing N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid. The method is rapid, high in yield and simple in separation and purification, and the used solvent is environment-friendly and is suitable for mass production.

A convenient preparation of several N-linked glycoamino acid building blocks for efficient solid-phase synthesis of glycopeptides

A high yielding route for the preparation of several Boc- and Fmoc-protected N-linked glycopeptide monomers was presented. It was found that these building blocks can be used for the solid-phase synthesis of glycopeptides or glycopeptidomimetics. A number of short glycopeptides- collagen mimics was prepared to demonstrate this applicability. The protocol employed was expected to be suitable for the synthesis of any desired N-linked glycopeptide.

Folate analogues. 33. Synthesis of folate and antifolate poly-γ-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cel

Representative examples of folate and antifolate poly-γ-glutamyl metabolites were synthesized via the [(9-fluorenylmethoxy)oxy]carbonyl (Fmoc) chemistry using the KH polyamide resin. Polyglutamate yields were consistently better in all cases compared to t