947669-86-5 Usage
Description
WWL113 is a selective inhibitor of carboxylesterase 3 (Ces3), a key enzyme involved in the regulation of lipolysis in adipocytes. It is a small molecule compound that specifically targets Ces3 without significantly affecting several related enzymes, making it a valuable tool for studying the role of Ces3 in lipid metabolism and energy homeostasis.
Uses
Used in Pharmaceutical Industry:
WWL113 is used as a research tool for studying the role of Ces3 in lipid metabolism and energy homeostasis. Its selective inhibition of Ces3 allows researchers to investigate the enzyme's function and potential therapeutic targets for treating metabolic disorders.
Used in Drug Development:
WWL113 is used as a lead compound for the development of novel drugs targeting Ces3. Its ability to selectively inhibit Ces3 without affecting related enzymes makes it a promising candidate for the treatment of metabolic disorders, such as obesity and type 2 diabetes.
Used in Metabolic Research:
WWL113 is used as a research tool to study the role of Ces3 in the regulation of lipolysis in adipocytes. By inhibiting Ces3, researchers can gain insights into the underlying mechanisms of lipid metabolism and energy homeostasis, potentially leading to the discovery of new therapeutic targets for metabolic disorders.
Used in Obesity Treatment:
WWL113 is used as a potential treatment for obesity by reducing basal lipolysis in adipocytes. Its selective inhibition of Ces3 can help decrease the breakdown of stored lipids, leading to a reduction in fat mass and weight loss.
Used in Type 2 Diabetes Management:
WWL113 is used as a potential treatment for type 2 diabetes by modulating lipid metabolism and improving insulin sensitivity. Its selective inhibition of Ces3 can help regulate glucose and lipid homeostasis, potentially leading to better glycemic control and reduced complications associated with diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 947669-86-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,7,6,6 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 947669-86:
(8*9)+(7*4)+(6*7)+(5*6)+(4*6)+(3*9)+(2*8)+(1*6)=245
245 % 10 = 5
So 947669-86-5 is a valid CAS Registry Number.
947669-86-5Relevant articles and documents
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases
Li, Weiwei,Blankman, Jacqueline L.,Cravatt, Benjamin F.
, p. 9594 - 9595 (2008/02/13)
Hydrolytic enzymes constitute one of the largest and most diverse protein classes in Nature and play key roles in nearly all physiological and pathological processes. The mammalian serine hydrolase superfamily contains a remarkable number of uncharacterized members, with at least 40-50% of these enzymes lacking experimentally verified endogenous substrates and products. Assignment of metabolic and cellular functions to these enzymes requires the development of pharmacological tools to selectively perturb their activity. We describe herein a functional proteomic strategy to systematically develop potent and selective inhibitors for uncharacterized serine hydrolases and its application to the brain-enriched enzyme α/β-hydrolase-6. We anticipate that the methods described herein will facilitate the development of selective chemical probes to annotate the metabolic and (patho)physiological functions of many of the uncharacterized serine hydrolases that currently populate eukaryotic and prokaryotic proteomes. Copyright
