94768-23-7Relevant academic research and scientific papers
A Continuous-Flow, Two-Step, Metal-Free Process for the Synthesis of Differently Substituted Chiral 1,2-Diamino Derivatives
Pirola, Margherita,Compostella, Maria Elena,Raimondi, Laura,Puglisi, Alessandra,Benaglia, Maurizio
, p. 1430 - 1438 (2018/02/09)
The enantioselective organocatalytic reduction of aryl-substituted nitroenamines was successfully performed under continuous-flow conditions. After a preliminary screening with a 10-μL microreactor, to establish the best reaction conditions, the reduction was scaled up in a 0.5-mL mesoreactor, without appreciable loss of enantioselectivity, that remained constantly higher than 90%. The in-flow nitro reduction was also accomplished, either by Raney nickel catalyzed hydrogenation or by a metal-free methodology based on the use of the very inexpensive and readily available reducing agent trichlorosilane. The final aim is to develop a two-step, continuous-flow process for the stereoselective, metal-free, catalytic synthesis of differently functionalized chiral 1,2-diamines.
One-pot protocol to synthesize N-(β-nitro)amides by tandem Henry/Ritter reaction
Ai, Wensi,Shi, Ronghua,Zhu, Liyan,Jiang, Dehong,Ma, Xiaobo,Yuan, Jilan,Wang, Zhouyu
, p. 24044 - 24048 (2015/03/30)
A novel, efficient and atom economical one pot protocol for the synthesis of N-(β-nitro)amides has been described by combining the Henry reaction with the Ritter reaction. The designed products could be obtained from easily available aldehydes, nitroalkan
An efficient way to synthesize N-(β-nitroalkyl) amides through ritter reaction
Shi, Ronghua,Ai, Wensi,He, Tao,Ma, Xiaobo,Qian, Shan,Wang, Zhouyu
, p. 720 - 726 (2016/03/25)
An efficient and simple way to synthesize N-(β-nitroalkyl) amides with broad substrate spectrum was developed. Various β-nitroarylethanols and nitriles were suitable substrate for the protocol. A series of N-(β-nitroalkyl) amides were synthesized through
Nitroacetamidation of Styrenes
Bloom, A. Jon,Fleischmann, Martin,Mellor, John M.
, p. 2357 - 2362 (2007/10/02)
Reaction of styrenes with nitronium tetrafluoroborate in acetonitrile affords good yields of products of nitroacetamidation.In all cases addition is highly regeoselective to give Markownikoff products.With trans-β-methylstyrene, conversion of the initial
