947699-23-2Relevant academic research and scientific papers
Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activities
Li, Jing,Huang, Wenlong,Zhang, Huibin,Wang, Xinyang,Zhou, Huiping
, p. 6891 - 6894 (2007)
The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on TNF-α and IL-6 secretion in mouse macrophages were also evaluated. Most of the tested compounds showed inhibitory effects, and the compounds with the structure of 12-hydroxy-14-dehydroandrographolide showed better inhibitory activity than the compounds with the structure of isoandrographolide.
