947740-45-6Relevant academic research and scientific papers
Diphenylprolinol silyl ether as a catalyst in an enantioselective, catalytic, tandem Michael/Henry reaction for the control of four stereocenters
Hayashi, Yujiro,Okano, Tsubasa,Aratake, Seiji,Hazelard, Damien
, p. 4922 - 4925 (2008/02/08)
(Chemical Equation Presented) A choice of three: The tandem Michael/ Henry reaction of a nitroalkene and pentane-1,5-dial (generated in situ) proceeded efficiently when diphenylprolinol silyl ether was used as an organocatalyst to afford substituted nitrocyclohexanecarbaldehydes with high diastereo- and enantioselectivity (see scheme; TMS: trimethylsilyl). Isomerization under basic or acidic conditions diastereoselectively converts the product into two stereoisomers, without compromising the enantioselectivity.
