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Usage

Uses

Used in Pharmaceutical Synthesis:
Glycine, N-(2-methoxyphenyl)is used as a key intermediate in the synthesis of pharmaceuticals, particularly for the production of angiotensin-converting enzyme (ACE) inhibitors. These inhibitors are crucial for treating hypertension and congestive heart failure, as they help regulate blood pressure and improve heart function.
Used in Organic Synthesis:
Glycine, N-(2-methoxyphenyl)serves as a versatile building block in the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with potential applications in different fields, including materials science and specialty chemicals.
Used in Research and Development:
Glycine, N-(2-methoxyphenyl)is utilized as a research tool in the study of biochemical processes and drug development. Its presence in experiments can provide insights into the mechanisms of action of various biological systems and contribute to the discovery of new therapeutic agents.
Used in Chemical Education:
In academic settings, Glycine, N-(2-methoxyphenyl)- can be employed in teaching and learning activities to demonstrate the principles of organic chemistry, particularly in the context of amino acid derivatives and their synthetic applications.
It is important to handle Glycine, N-(2-methoxyphenyl)with care due to its potential health and environmental hazards if not used properly. Proper safety measures and disposal methods should be followed to mitigate any risks associated with its use.

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 69825-50-9 ethyl 2-((2-methoxyphenyl)amino)acetate 
• 584-08-7 potassium carbonate 
• 578-57-4 2-bromoanisole 

Downstream Products

• 14606-02-1 4-bromo-3-(2-methoxy-phenyl)-sydnone 
• 1448616-37-2 (S)-N-((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-(2-((2-methoxyphenyl)amino)acetamido)-4-methylpentanamide 
• 1448616-15-6 (S)-tert-butyl 2-(2-((2-methoxyphenyl)amino)acetamido)-4-methylpentanoate 
• 3483-15-6 N-(2-methoxyphenyl)sydnone 
• 121163-59-5 N-(2-methoxy-phenyl)-N-nitroso-glycine 

Relevant academic research and scientific papers

Water-Involved Ring-Opening of 4-Phenyl-1,2,4-triazoline-3,5-dione for “Photo-Clicked” Access to Carbamoyl Formazan Photoswitches In Situ

Cyclic azodicarbonyl derivatives, particularly 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD), commonly serve as arenophile, dienophile, enophile and electrophile. Perplexed by its instability in aqueous environment, there are few studies focused on the transient intermediate produced by hydrolysis of PTAD to achieve synthetic significance. Herein, we describe a “photo-click” method that involves nitrile imine (NI) from diarylsydnone to capture the diazenecarbonyl-phenyl-carbamic acid (DACPA) generated by water-promoted ring-opening of PTAD. DFT calculation reveal that H-bonding interactions between PTAD and water are vital to form DACPA which exhibited an umpolung effect during ligation by nature bond orbit (NBO) analysis. The ultra-fast ligation resulted in carbamoyl formazans, as a unique Z?E photo-switchable linker on target molecules, including peptide and drugs, with excellent anti-fatigue performance. This strategy is showcased to construct highly functionalized carbamoyl formazans in situ for photo-pharmacology and material studies, which also expands the chemistry of PTAD in aqueous media.

Microwave-assisted synthesis of N-arylglycines: Improvement of sydnone synthesis

Reactions of anilines with ethyl bromoacetate under microwave irradiation have afforded N-arylglycines that are subsequently converted to their N-nitroso derivatives with a combination of silica chloride or periodic acid, wet SiO2 and sodium nitrite in CH2Cl2 with satisfactory yields. In the final step, the use of 1,3-dibromo-5,5-dimethylhydantoin (DBH) as a new and effective reagent for dehydration of N-nitroso-N-arylglycines to sydnones was successfully examined.

Piperidine derivatives with PAF antagonist activity

Compounds of general formula I and their salts and solvates are PAF antagonists and as such are useful in the treatment of various diseases or disorders mediated by PAF. Pharmaceutical compositions including these compounds and processes for their prepara