94800-23-4

Basic information

• Product Name: Glycine, N-(2-methoxyphenyl)-
• Synonyms: Glycine, N-(2-methoxyphenyl)- ;N-(2-Methoxyphenyl)glycine;[(2-Methoxyphenyl)amino]acetic acid
• CAS NO: 94800-23-4
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.18854
• Mol File: 94800-23-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Glycine, N-(2-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-(2-methoxyphenyl)-(94800-23-4)
• EPA Substance Registry System: Glycine, N-(2-methoxyphenyl)-(94800-23-4)

Safety Data

• Hazardous Substances Data: 94800-23-4(Hazardous Substances Data)

Usage

General Description

Glycine, N-(2-methoxyphenyl)-, also known as N-(2-Methoxyphenyl)glycine or Mpg, is a chemical compound with the molecular formula C9H11NO3. It is a derivative of the amino acid glycine, with a 2-methoxyphenyl group attached to the nitrogen atom. Glycine, N-(2-methoxyphenyl)- is commonly used in the synthesis of pharmaceuticals, such as angiotensin-converting enzyme (ACE) inhibitors, which are used to treat hypertension and congestive heart failure. It also has potential applications as a building block in the synthesis of various organic compounds, and as a research tool in the study of biochemical processes and drug development. However, it is important to handle this chemical with caution, as it may pose health and environmental hazards if not used properly.

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 105-36-2 ethyl bromoacetate 
• 69825-50-9 ethyl 2-((2-methoxyphenyl)amino)acetate 
• 584-08-7 potassium carbonate 
• 578-57-4 2-bromoanisole 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 1448616-37-2 (S)-N-((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-(2-((2-methoxyphenyl)amino)acetamido)-4-methylpentanamide 
• 1448616-15-6 (S)-tert-butyl 2-(2-((2-methoxyphenyl)amino)acetamido)-4-methylpentanoate 
• 14606-02-1 4-bromo-3-(2-methoxy-phenyl)-sydnone 
• 3483-15-6 N-(2-methoxyphenyl)sydnone 
• 121163-59-5 N-(2-methoxy-phenyl)-N-nitroso-glycine 

Relevant articles and documents

Water-Involved Ring-Opening of 4-Phenyl-1,2,4-triazoline-3,5-dione for “Photo-Clicked” Access to Carbamoyl Formazan Photoswitches In Situ

Cyclic azodicarbonyl derivatives, particularly 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD), commonly serve as arenophile, dienophile, enophile and electrophile. Perplexed by its instability in aqueous environment, there are few studies focused on the transient intermediate produced by hydrolysis of PTAD to achieve synthetic significance. Herein, we describe a “photo-click” method that involves nitrile imine (NI) from diarylsydnone to capture the diazenecarbonyl-phenyl-carbamic acid (DACPA) generated by water-promoted ring-opening of PTAD. DFT calculation reveal that H-bonding interactions between PTAD and water are vital to form DACPA which exhibited an umpolung effect during ligation by nature bond orbit (NBO) analysis. The ultra-fast ligation resulted in carbamoyl formazans, as a unique Z?E photo-switchable linker on target molecules, including peptide and drugs, with excellent anti-fatigue performance. This strategy is showcased to construct highly functionalized carbamoyl formazans in situ for photo-pharmacology and material studies, which also expands the chemistry of PTAD in aqueous media.

Piperidine derivatives with PAF antagonist activity

Compounds of general formula I and their salts and solvates are PAF antagonists and as such are useful in the treatment of various diseases or disorders mediated by PAF. Pharmaceutical compositions including these compounds and processes for their prepara