948015-63-2

Basic information

• Product Name: 1H-Indole-4-carboxylic acid, 6-[[(1,1-diMethylethoxy)carbonyl]aMino]-
• Synonyms: 1H-Indole-4-carboxylic acid, 6-[[(1,1-diMethylethoxy)carbonyl]aMino]-
• CAS NO: 948015-63-2
• Molecular Formula: C14H16N2O4
• Molecular Weight: 276.28784
• Mol File: 948015-63-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole-4-carboxylic acid, 6-[[(1,1-diMethylethoxy)carbonyl]aMino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-4-carboxylic acid, 6-[[(1,1-diMethylethoxy)carbonyl]aMino]-(948015-63-2)
• EPA Substance Registry System: 1H-Indole-4-carboxylic acid, 6-[[(1,1-diMethylethoxy)carbonyl]aMino]-(948015-63-2)

Safety Data

• Hazardous Substances Data: 948015-63-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
1H-Indole-4-carboxylic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]is used as a key intermediate in the synthesis of new pharmaceuticals for [application reason]. Its indole ring and carboxylic acid group provide opportunities for structural modifications and the development of novel drug candidates with potential therapeutic benefits.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1H-Indole-4-carboxylic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]is used as a research compound to explore its biological activity and potential applications in treating various disorders. Its unique chemical structure allows for the investigation of its interactions with biological targets and the evaluation of its efficacy and safety in preclinical studies.
Note: The specific application reason for the use of 1H-Indole-4-carboxylic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]in pharmaceutical development and medicinal chemistry research is not provided in the materials. The placeholder "[application reason]" should be replaced with the actual reason based on the specific context or research findings.

Upstream product

• 103956-00-9 methyl 6-amino-1H-indole-4-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 731810-56-3 methyl 6-((tert-butoxycarbonyl)amino)-1H-indole-4-carboxylate 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

2-AMINOQUINAZOLINE DERIVATIVE

An object of the present invention is to provide compounds which are useful as protein kinase inhibitors. Disclosed is a 2-aminoquinazoline derivative represented by the following formula (I): wherein R1 represents a lower alkyl group which may be substituted with a halogen atom, or a halogen atom; R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a halogen atom, a hydroxyl group, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted acylamino group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, or a substituted or unsubstituted lower alkylureido group; and X, Y and Z each independently represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a halogen atom, a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group, a cyano group, a carbamoyl group, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted lower alkoxycarbonylamino group, a substituted or unsubstituted lower alkylaminocarbonyl group, a lower alkylsulfonylamino group, a substituted or unsubstituted lower alkylureido group, or a substituted or unsubstituted acylamino group, or X and Y may be combined to form a 5- to 6-membered ring forming a bicyclic fused ring, wherein the 5- to 6-membered ring may optionally have a substituent, provided that when X and Y are not combined to form a fused ring, R2 represents a hydrogen atom and, when X and Y are combined to form a fused ring, a saturated or unsaturated, bicyclic alicyclic or heterocyclic fused ring can be formed.