948037-40-9Relevant academic research and scientific papers
Synthesis of (purin-6-yl)acetates and their transformations to 6-(2-hydroxyethyl)-and 6-(carbamoylmethyl)purines
Hasnik, Zbynek,Pohl, Radek,Klepetarova, Blanka,Hocek, Michal
experimental part, p. 1035 - 1059 (2010/04/24)
A novel approach to the synthesis of (purin-6-yl)acetates was developed based on Pdcatalyzed cross-coupling reactions of 6-chloropurines with a Reformatsky reagent. Their reduction with NaBH4 and treatment with MnO2 gave 6-(2-hydroxyethyl)purines, while reactions with amines in presence of NaCN afforded 6-(carbamoylmethyl)purines. Mesylation of the 6-(2-hydroxyethyl)purines followed by nucleophilic substitutions gave rise to several 6-(2-substituted ethyl)purines. This methodology was successfully applied to the synthesis of substituted purine bases and nucleosides for cytostatic and antiviral activity screening. None of the compounds exerted significant activity.
