94805-51-3

Usage

Uses

Used in Pharmaceutical Industry:
5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE is used as a building block in drug synthesis for its potential to contribute to the development of new pharmaceutical compounds. Its unique structure, which includes a fluorine atom and an indole ring, allows for the creation of molecules with specific therapeutic properties.
Used in Chemical Industry:
In the chemical industry, 5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE serves as an intermediate in the production of organic compounds. Its presence in these compounds can influence their reactivity, stability, and other chemical properties, making it a useful component in the synthesis of various organic materials.
Used in Research and Development:
5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE is utilized in research and development as a tool to study the structure-activity relationships of drugs. Understanding how the compound's structure affects its activity can provide insights into the design of more effective pharmaceuticals and contribute to the advancement of drug discovery processes.

InChI:InChI=1/C6H4N2O/c7-4-5-1-2-8-6(9)3-5/h1-3H,(H,8,9)

Upstream product

• 14906-59-3 4-cyanopyridine N-oxide 
• 100-48-1 pyridine-4-carbonitrile 
• 504-29-0 2-aminopyridine 
• 42182-27-4 4-cyanopyridin-2-amine 
• 552331-00-7 4-(iodo)pyridin-2-amine 

Downstream Products

• 1608144-25-7 2-amino-2-(5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)furo[2,3-b]pyridin-2-yl)propane-1,3-diol 
• 1608146-70-8 5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-3-iodopyridin-2-ol 
• 1608146-72-0 tert-butyl N-(5-{5-[5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl]furo[2,3-b]pyridin-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate 

Relevant academic research and scientific papers

ORGANIC COMPOUNDS

Novel benzofuran derivatives are disclosed. The derivatives have S1P1 receptor activity and/or disease modifying activity and find use in the treatment of conditions or diseases associated with the immune, vascular and nervous systems in animals and/or humans

PROCESS FOR PRODUCTION OF 2-HYDROXY-4-SUBSTITUTED PYRIDINES

A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided. According to the process, a function of a microorganism or a product obtained therefrom is exerted on a 4-substituted pyridine of the general formula (1): wherein R is a methyl group, a carboxyl group, a carbamoyl group, a hydroxyiminomethyl group or a cyano group, to obtain the corresponding 2-hydroxy-4-substituted pyridine compound. The novel microorganisms are the Delftia species YGK-A649 (FERM BP-10389), Delftia species YGK-C217 (FERM BP-10388), or Acidovorax species YGK-A854 (FERM BP-10387) and the novel compound is a 2-hydroxy-4-pyridinaldoxime.

Bifunctional catalysis of ester aminolysis - A computational and experimental study

Various pathways for the reaction of methylamine with methyl acetate catalyzed by 2(1H)-pyridone have been investigated at the Becke3LYP/6-31G**//HF/6-31G** level of theory. The most favorable pathway consists of a one-step reaction, in which all bond-forming and -breaking processes occur in concert. These modeling studies also show the pyridone to function as an acid, which led to the investigation of several substituted pyridones. 4-Cyano-, 3-cyano-6-methyl-, and 3-cyano-2(1H)-pyridone have indeed been shown to provide better catalysis in the ester aminolysis reaction by ab initio modeling at the Becke3LYP/6-31G**//HF/3-21G level. In order to verify the theoretical results, the catalytic activities of various substituted 2-pyridones in the reaction of n-butylamine with p-nitrophenyl acetate in chlorobenzene solution have been determined. The observed catalytic rate constants are indeed in agreement with the theoretical predictions. Other catalyst characteristics such as solubility and state of aggregation are, however, also of paramount importance in this reaction. VCH Verlagsgesellschaft mbH, 1996.