948052-30-0Relevant academic research and scientific papers
Synthesis of biologically important angiotensin-II and angiotensin-IV peptides by using 4-(2',4'-dimethoxypenyl-fmoc-aminomethyl)phenoxy resin
Selvam,Rohini,Arunan,Subashchandran
, p. 8673 - 8676 (2013)
In peptide chemistry, there is the goal to produce pure biologically active peptides with the highest possible efficiency, even its possible by chemical synthesis purity and yield as a major problem. In this work, we focus to overcome above difficulty by novel synthetic approach. Angiotensin an oligopeptide is a hormone and a powerful dipsogen, which exhibits a wide range of biological activities, the 8-amino acid sequence Angiotensin-II and 6-amino acid sequence. Angiotensin-IV were synthesized by using 4-(2',4'- dimethoxyphenyl- Fmoc-aminomethyl)phenoxy resin, the modified Fmoc-chemistry and effective hydroxybenzenetriazole, N,N'-diisopropylcarbodiimide coupling and activation methods was used. The yield and chromatographic purities were compared.
